GBA1 and NEDD4

Number of citations of the paper that reports this interaction (PubMedID 19953087)
60

Data Source:
BioGRID (enzymatic study)

		GBA1	NEDD4
Description		glucosylceramidase beta 1	NEDD4 E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Extracellular Space Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Membrane Lysosomal Lumen Extracellular Exosome	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Apicolateral Plasma Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Galactosylceramidase Activity Glucosylceramidase Activity Signaling Receptor Binding Scavenger Receptor Binding Protein Binding Beta-glucosidase Activity Transferase Activity Glycosyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Glucosyltransferase Activity Steryl-beta-glucosidase Activity	Ubiquitin-protein Transferase Activity Protein Binding Channel Inhibitor Activity Transferase Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ionotropic Glutamate Receptor Binding Ubiquitin Binding Transmembrane Transporter Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding
	Biological Process	Mitophagy Lipid Metabolic Process Sphingolipid Metabolic Process Glucosylceramide Metabolic Process Glucosylceramide Catabolic Process Autophagy Mitochondrion Organization Lysosome Organization Central Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Determination Of Adult Lifespan Cellular Response To Starvation Response To PH Negative Regulation Of Macromolecule Metabolic Process Microglia Differentiation Regulation Of Macroautophagy Antigen Processing And Presentation Lipid Storage Cerebellar Purkinje Cell Layer Formation Pyramidal Neuron Differentiation Respiratory Electron Transport Chain Termination Of Signal Transduction Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production T Cell Differentiation In Thymus Response To Testosterone Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Cell Maturation Brain Morphogenesis Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Nervous System Process Neuromuscular Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Neuron Apoptotic Process Establishment Of Skin Barrier Microglial Cell Proliferation Motor Behavior Cellular Response To Tumor Necrosis Factor Hematopoietic Stem Cell Proliferation Response To Dexamethasone Lymphocyte Migration Response To Thyroid Hormone Skin Epidermis Development Beta-glucoside Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Neuronal Action Potential Autophagosome Organization Positive Regulation Of Type 2 Mitophagy Lysosomal Protein Catabolic Process Regulation Of Lysosomal Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Targeting To Lysosome Sodium Ion Transport Immune Response DNA Damage Response Lysosomal Transport Nervous System Development Neuromuscular Junction Development Regulation Of Cell Communication Negative Regulation Of Sodium Ion Transport Regulation Of Macroautophagy Protein Ubiquitination Regulation Of Signaling Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV T Cell Activation Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Formation Of Structure Involved In A Symbiotic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Viral Budding Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Biological Quality Protein K63-linked Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Pathways		Association of TriC/CCT with target proteins during biosynthesis Glycosphingolipid catabolism	ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs		scyllo-inositol N-acetyl-alpha-D-glucosamine Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Gaucher disease
GWAS			Appendicular lean mass ( 33097823) Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 24292274 28165464) Dupuytren's disease ( 28886342) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Joint mobility (Beighton score) ( 27182965) Keloid ( 20711176) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: NEDD4 OGT PSAP SNCA TRIP12	282 interacting genes: ABCB1 ABL1 ABL2 ADRB2 AK6 AKT1 AKT3 AMOT AMOTL1 AMPD2 ANK3 ANKRD13D ANXA13 AP1G2 ARID1A ASPSCR1 AURKC BAIAP2 BAIAP2L1 BIRC6 BMPR1A C15orf62 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDIP1 CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CRTC2 CUEDC1 DAZAP2 DCUN1D1 DDN DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EGR1 ENTREP1 EP300 EPHA5 EPRS1 EPS15 ERBB3 ERBB4 ERMN ERRFI1 ESS2 FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FOXJ3 FYN GABARAP GABARAPL1 GABARAPL2 GBA1 GFUS GJA1 GRB10 GRIN2A GRK4 GRK7 H3-3A HGS HMCES HMGCL HNRNPK HNRNPL HNRNPU HNRNPUL1 HRAS IFITM3 IGF1R IL1B IRS1 IRS2 JHY JUN KCNAB1 KCNAB2 KCNJ16 KIFC3 KLF5 KRAS LATS1 LDLRAD3 LDLRAD4 LINC01198 LITAF LUC7L2 MAML2 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MS4A10 MTMR4 MYCN MYCT1 MYO15B N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NRAS NSRP1 NUDT21 NUMB PARP16 PAX7 PDGFRB PIP4P2 PIP5K1A PIP5K1C PKN2 PLK1 PLK2 PMEPA1 POLR1C POLR2A POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRR7 PRRG2 PRRG4 PSMD4 PTEN PYM1 RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RBM14 RET RFT1 RHBDD1 RHBDD2 RNF11 RNF38 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUVBL1 SAAL1 SAMSN1 SAV1 SCAMP3 SCN10A SCN1A SCN5A SCNN1A SCNN1B SCNN1G SEPTIN9 SFTPC SGK1 SGK2 SH3KBP1 SHISA6 SHTN1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SQSTM1 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 STRIP2 SULF1 SYK SYNPO2 SYT1 TAF1B TBC1D7 TCEANC TCP11L1 TEAD2 TGFB1I1 THOC1 THRAP3 TMEM139 TMEM252 TMEM51 TNIK TOM1 TOM1L2 TP53BP2 TP63 TP73 TRERF1 TRIM44 TRIM52 TRPV6 TTYH2 TTYH3 TULP4 TUSC2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2L6 UBE2M UBOX5 URI1 UVRAG VDAC2 VDAC3 WBP1 WBP2 WEE1 YES1 YOD1 ZC3H14
Entrez ID		2629	4734
HPRD ID		06973	03786
Ensembl ID		ENSG00000177628	ENSG00000069869
Uniprot IDs		A0A068F658 B7Z6S9 P04062	P46934
PDB IDs		1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX 6MOZ 6Q1N 6Q1P 6Q6K 6Q6L 6Q6N 6T13 6TJJ 6TJK 6TJQ 6TN1 6YTP 6YTR 6YUT 6YV3 6Z39 6Z3I 7NWV 8AWK 8AWR 8AX3 8P3E 8P41 9F9Z 9FA3 9FA6 9FAD 9FAL 9FAY 9FAZ 9FB2 9FDI	2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8 4N7F 4N7H 5AHT 5C7J 5C91
Enriched GO Terms of Interacting Partners?		Protein Domain Specific Binding Protein Localization To Lysosome Receptor Internalization Regulation Of Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Autophagy Formation Of Structure Involved In A Symbiotic Process Regulation Of Lipid Metabolic Process Ganglioside GM3 Binding Ganglioside GP1c Binding Lipid Binding Positive Regulation Of Beta-galactosidase Activity Enzyme Activator Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Vacuole Channel Inhibitor Activity Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Heterochromatin Boundary Formation Phospholipid Binding Negative Regulation Of Protein Catabolic Process Lysosomal Transport Phosphothreonine Residue Binding Ganglioside GT1b Binding Ganglioside GM1 Binding Negative Regulation Of Serotonin Uptake Negative Regulation Of Protein-containing Complex Assembly Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Generation Of Precursor Metabolites And Energy Protein O-acetylglucosaminyltransferase Activity Perinuclear Region Of Cytoplasm Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Vacuolar Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Synapse Assembly Regulation Of Protein Localization To Cell Periphery Regulation Of Serotonin Uptake Cell Cortex Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein-containing Complex	Protein Kinase Activity Kinase Activity Protein Phosphorylation Intracellular Signal Transduction ATP Binding Nucleotide Binding Phosphorylation WW Domain Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Transferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Serine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Protein Autophosphorylation Signal Transduction Cytoplasm Regulation Of Protein Modification Process Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process MAPK Cascade Positive Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Macromolecule Metabolic Process Positive Regulation Of Cell Communication Apoptotic Process Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Positive Regulation Of Signaling Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Programmed Cell Death Cell Surface Receptor Signaling Pathway Cell Death Regulation Of Apoptotic Process Nucleoplasm Regulation Of Biological Quality Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Projection Organization Response To Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Communication
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