GBA and PSAP

Number of citations of the paper that reports this interaction (PMID 7613473)
5

Data Source:
HPRD (in vitro)

		GBA	PSAP
Gene Name		glucosidase, beta, acid	prosaposin
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleoplasm Nucleolus Mitochondrion Lysosomal Membrane Golgi Apparatus Integral Component Of Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Glucosylceramidase Activity Receptor Binding Protein Binding	Protein Binding Enzyme Activator Activity Lipid Binding
	Biological Process	Carbohydrate Metabolic Process Sphingolipid Metabolic Process Glucosylceramide Catabolic Process Glycosphingolipid Metabolic Process Response To PH Termination Of Signal Transduction Negative Regulation Of Interleukin-6 Production Regulation Of Water Loss Via Skin Response To Testosterone Positive Regulation Of Protein Dephosphorylation Negative Regulation Of MAP Kinase Activity Skin Morphogenesis Response To Estrogen Small Molecule Metabolic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Inflammatory Response Response To Glucocorticoid Cellular Response To Tumor Necrosis Factor Response To Thyroid Hormone	Platelet Degranulation Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Lipid Transport Blood Coagulation Regulation Of Lipid Metabolic Process Platelet Activation Positive Regulation Of Catalytic Activity Regulation Of MAPK Cascade Small Molecule Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Cellular Response To Organic Substance
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Peptide ligand-binding receptors Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation
Drugs		Myo-Inositol 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL	Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases
GWAS		Parkinson's disease ( 22451204 21738487) Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		2 interactors: NEDD4 PSAP	14 interactors: BACE1 BRCA1 CD1B CELSR1 COPS6 CTSD GBA MAFF SGK223 SMAD2 SMAD9 UBE3A USP4 ZBED1
Entrez ID		2629	5660
HPRD ID		06973	01460
Ensembl ID		ENSG00000177628	ENSG00000197746
Uniprot IDs		B7Z5G2 B7Z6S1 B7Z6S9 F5H241 J3KQG4 J3KQK9 P04062	P07602
PDB IDs		1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL	1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ
Enriched GO Terms of Interacting Partners?		Transmission Of Virus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Development Involved In Symbiotic Interaction Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Glucocorticoid Receptor Signaling Pathway Cell Activation Neuronal Ion Channel Clustering Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Lysosome Epithelial Cell Differentiation Involved In Prostate Gland Development Receptor Catabolic Process Neuron Development Prostate Gland Growth Protein Targeting To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Neuron Differentiation Regulation Of Potassium Ion Transmembrane Transporter Activity Neuron Maturation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein K63-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Endocardial Cushion Development Regulation Of Potassium Ion Transmembrane Transport Protein Monoubiquitination Receptor Internalization Vesicle-mediated Transport Lysosomal Transport Neuromuscular Junction Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Generation Of Neurons Respiratory Gaseous Exchange Regulation Of DNA-templated Transcription In Response To Stress Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Neurogenesis Cellular Response To UV Regulation Of Potassium Ion Transport Outflow Tract Morphogenesis Tissue Development Regulation Of Sodium Ion Transport Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Intracellular Signal Transduction Prostate Gland Development Platelet Degranulation Regulation Of Dendrite Morphogenesis Cell Development Intracellular Steroid Hormone Receptor Signaling Pathway	Regulation Of Protein Ubiquitination Androgen Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Histone H4-K20 Methylation Sperm Entry Positive Regulation Of Histone H4-K16 Acetylation Protein Localization Involved In Establishment Of Planar Polarity Intracellular Steroid Hormone Receptor Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Cellular Protein Modification Process Protein Metabolic Process Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Establishment Of Body Hair Planar Orientation Positive Regulation Of Histone H3-K9 Acetylation Lateral Sprouting Involved In Lung Morphogenesis Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Glucosylceramide Catabolic Process Urogenital System Development Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Organ Growth Cellular Response To Tumor Necrosis Factor Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Zygotic Specification Of Dorsal/ventral Axis Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Protein Modification By Small Protein Removal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Mesonephros Development Response To Tumor Necrosis Factor Glucosylceramide Metabolic Process Cellular Response To Indole-3-methanol Establishment Of Planar Polarity Of Embryonic Epithelium Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Mesoderm Development Negative Regulation Of Centriole Replication Primary MiRNA Processing Sphingosine Biosynthetic Process Embryo Development Kidney Epithelium Development Dosage Compensation By Inactivation Of X Chromosome Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Sphingoid Biosynthetic Process
Tagcloud ?		ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor	ac acinar adenocarcinoma cdx2 cea ck20 ck7 dac debated erg gleason hmwck immunomarkers ki lysozyme morphotypes overlap p16 p504s p63 patchy pax prolactin prostatic prostein psma slides villin
Tagcloud (Difference) ?		ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor	ac acinar adenocarcinoma cdx2 cea ck20 ck7 dac debated erg gleason hmwck immunomarkers ki lysozyme morphotypes overlap p16 p504s p63 patchy pax prolactin prostatic prostein psma slides villin
Tagcloud (Intersection) ?