PRRG2 and NKG7

		PRRG2	NKG7
Description		proline rich and Gla domain 2	natural killer cell granule protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	Lysosome Plasma Membrane Membrane Cytolytic Granule Cytolytic Granule Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Protein Binding
	Biological Process	Proteolysis Blood Coagulation	Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Inflammatory Response Killing Of Cells Of Another Organism CD4-positive, Alpha-beta T Cell Activation Natural Killer Cell Mediated Cytotoxicity Defense Response To Protozoan Natural Killer Cell Degranulation Positive Regulation Of Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 33536631) Red blood cell count ( 27863252 32888494) Schizophrenia ( 25056061 29483656 30285260)	Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		8 interacting genes: CRK FAM221A FATE1 NEDD4 NEDD4L SGTA WWTR1 YAP1	49 interacting genes: AGTRAP AMIGO1 AQP6 ARL13B ATP6AP2 BAMBI CD53 CD79A CLDN7 CLEC2D CLEC4E CLSTN3 CREB3 EBP EDA2R ERGIC3 FAM209A FAM210B FFAR2 FKBP7 FNDC9 GJA5 GORAB GPX8 ISLR2 KLRC1 LHFPL5 LMNA MFSD6 MGST3 MS4A3 MSR1 MUC1 OPRK1 PEX12 RAMP1 RNF24 SLC10A1 SLC18A2 SLC30A8 SLC35H1 STOM STX1A TLCD4 TMEM106C TMEM130 TMEM139 TMEM80 TMEM88
Entrez ID		5639	4818
HPRD ID		09189	16188
Ensembl ID		ENSG00000126460	ENSG00000105374
Uniprot IDs		O14669 Q8TAS3	A0A0B4J2A6 Q16617
PDB IDs		9BVP 9BVQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Dendrite Development Negative Regulation Of Sodium Ion Transport Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Proline-rich Region Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Bicellular Tight Junction Hippo Signaling Positive Regulation Of Cell Growth Negative Regulation Of Potassium Ion Transport Heart Process Regulation Of Neuron Projection Development Neuromuscular Junction Development Plasma Membrane Bounded Cell Projection Organization Neuron Projection Development Plasma Membrane Positive Regulation Of Protein Catabolic Process Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Meiotic Spindle Elongation Enterocyte Differentiation Protein Monoubiquitination Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Growth Macromolecule Catabolic Process Mesenchyme Development Regulation Of Growth Regulation Of Dendrite Morphogenesis Helper T Cell Diapedesis Regulation Of Lymphocyte Migration Protein Phosphorylated Amino Acid Binding Cell Projection Organization Response To Cholecystokinin Regulation Of Developmental Process Receptor Internalization Channel Inhibitor Activity Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation	Membrane Plasma Membrane Protein Binding
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