PRRG2 and FAM221A

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PRRG2	FAM221A
Name		proline rich and Gla domain 2	family with sequence similarity 221 member A
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	None
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Protein Binding
	Biological Process	Proteolysis Blood Coagulation	None
GWAS		Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Red blood cell count ( 27863252 32888494 ) Schizophrenia ( 25056061 29483656 30285260 )	No GWAS studies recorded
Novel Interactors		6 novel interactors: CCL4 CYTH2 NKG7 PPP2R1A RTN4RL1 SNX15	None recorded
Interacting Genes		8 interacting genes: CRK FAM221A FATE1 NEDD4 NEDD4L SGTA WWTR1 YAP1	15 interacting genes: ANKS1A CDPF1 CYSRT1 HOXA1 KRTAP1-1 KRTAP21-2 KRTAP4-11 LHX3 MEOX2 NBPF19 NOTCH2NLA PFDN5 PRRG2 SUMO3 ZNF417
Entrez ID		5639	340277
HPRD ID		09189	14706
Ensembl ID		ENSG00000126460	ENSG00000188732
Uniprot IDs		O14669 Q8TAS3	A4D161 B8ZZQ8
PDB IDs		9BVP 9BVQ	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Dendrite Development Negative Regulation Of Sodium Ion Transport Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Proline-rich Region Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Bicellular Tight Junction Hippo Signaling Positive Regulation Of Cell Growth Negative Regulation Of Potassium Ion Transport Heart Process Regulation Of Neuron Projection Development Neuromuscular Junction Development Plasma Membrane Bounded Cell Projection Organization Neuron Projection Development Plasma Membrane Positive Regulation Of Protein Catabolic Process Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Meiotic Spindle Elongation Enterocyte Differentiation Protein Monoubiquitination Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Growth Macromolecule Catabolic Process Mesenchyme Development Regulation Of Growth Regulation Of Dendrite Morphogenesis Helper T Cell Diapedesis Regulation Of Lymphocyte Migration Protein Phosphorylated Amino Acid Binding Cell Projection Organization Response To Cholecystokinin Regulation Of Developmental Process Receptor Internalization Channel Inhibitor Activity Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation	Semicircular Canal Formation Abducens Nerve Formation Inner Ear Development Optokinetic Behavior RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Intermediate Filament