PRRG2 and SNX15

Data Source: HiPPIP (Novel)

		PRRG2	SNX15
Name		proline rich and Gla domain 2	sorting nexin 15
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Protein Binding Lipid Binding Phosphatidylinositol Binding
	Biological Process	Proteolysis Blood Coagulation	Intracellular Protein Transport Protein Transport
GWAS		Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Red blood cell count ( 27863252 32888494 ) Schizophrenia ( 25056061 29483656 30285260 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: CRK FAM221A FATE1 NEDD4 NEDD4L SGTA WWTR1 YAP1	6 interacting genes: ARL6IP1 KDM1A RABAC1 REEP6 RTN4 SARAF
Entrez ID		5639	29907
HPRD ID		09189	12073
Ensembl ID		ENSG00000126460	ENSG00000110025
Uniprot IDs		O14669 Q8TAS3	Q9NRS6
PDB IDs		9BVP 9BVQ	6ECM 6MBI
GO Terms Enriched among Interactors		Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Dendrite Development Negative Regulation Of Sodium Ion Transport Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Proline-rich Region Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Bicellular Tight Junction Hippo Signaling Positive Regulation Of Cell Growth Negative Regulation Of Potassium Ion Transport Heart Process Regulation Of Neuron Projection Development Neuromuscular Junction Development Plasma Membrane Bounded Cell Projection Organization Neuron Projection Development Plasma Membrane Positive Regulation Of Protein Catabolic Process Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Meiotic Spindle Elongation Enterocyte Differentiation Protein Monoubiquitination Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Growth Macromolecule Catabolic Process Mesenchyme Development Regulation Of Growth Regulation Of Dendrite Morphogenesis Helper T Cell Diapedesis Regulation Of Lymphocyte Migration Protein Phosphorylated Amino Acid Binding Cell Projection Organization Response To Cholecystokinin Regulation Of Developmental Process Receptor Internalization Channel Inhibitor Activity Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation	Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Membrane Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Epithelial To Mesenchymal Transition Telomeric Repeat-containing RNA Binding Mesenchymal Cell Differentiation FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Protein Localization To Endoplasmic Reticulum MRF Binding Protein Demethylase Activity Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Cell Migration Involved In Vasculogenesis Regulation Of Branching Morphogenesis Of A Nerve Intracellular Sphingolipid Homeostasis Central Nervous System Vasculogenesis Endoplasmic Reticulum Tubular Network Membrane Response To Fungicide Guanine Metabolic Process Sec61 Translocon Complex Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Artery Morphogenesis Histone H3K4 Demethylase Activity Cerebral Cortex Radial Glia-guided Migration Regulation Of L-glutamate Import Across Plasma Membrane Endoplasmic Reticulum-plasma Membrane Contact Site Regulation Of Artery Morphogenesis Histone H3K9 Demethylase Activity Positive Regulation Of Hepatocyte Proliferation Nuclear Pore Complex Assembly Regulation Of Toll-like Receptor 9 Signaling Pathway