GKN1 and PLPP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GKN1	PLPP6
Description		gastrokine 1	phospholipid phosphatase 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Endomembrane System Secretory Granule	Nucleus Nuclear Envelope Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane
	Molecular Function	Protein Binding Growth Factor Activity	Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Lyase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Isoprenoid Diphosphate Phosphatase Activity
	Biological Process	Signal Transduction Digestion Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Cell Division	Immune System Process Lipid Metabolic Process Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Protein Prenylation Geranyl Diphosphate Metabolic Process Innate Immune Response Farnesyl Diphosphate Catabolic Process Phospholipid Dephosphorylation Geranylgeranyl Diphosphate Catabolic Process Positive Regulation Of Neutrophil Activation
Pathways			Cholesterol biosynthesis
Drugs
Diseases
GWAS
Interacting Genes		12 interacting genes: AQP6 CDC27 FAM209A MFF PLPP6 SERP1 SERP2 SMCO4 TMEM179B TREX1 UBE2J1 VAPA	57 interacting genes: AMIGO1 AQP6 AQP8 BTN2A1 BTNL9 C16orf92 CD79A CIAO2A CLDN15 CLDN9 CLEC4M CLN5 COMT CREB3L1 EBP FAM174A FAM209A FAM210B FKBP7 FNDC9 FXYD3 GJB5 GKN1 GORAB GPX8 HSH2D IL10RA IL13RA2 KASH5 LAYN LDLRAD1 MMGT1 MS4A3 MUC1 NCR3LG1 PDGFRA PDZK1IP1 PHACTR3 PRLR PVR RETREG3 RNF170 RNF5 SEC11C SHISAL1 SIGLEC12 SLC7A14 SMAGP SOCS4 SSMEM1 STX1A SYNE4 SYNPR TMEM106C TMIE TNFRSF10D VSIR
Entrez ID		56287	403313
HPRD ID		16217	17397
Ensembl ID		ENSG00000169605	ENSG00000205808
Uniprot IDs		A0A8I5KHR1 Q53YU7 Q9NS71	Q8IY26
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Nitrate Transmembrane Transporter Activity Membrane Azurophil Granule Membrane Endoplasmic Reticulum Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Response To Endoplasmic Reticulum Stress Nuclear Inner Membrane Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Cellular Response To Type I Interferon DNA Exonuclease Activity Retrotransposition Transposition Endoplasmic Reticulum Unfolded Protein Response Response To Unfolded Protein FFAT Motif Binding DNA Synthesis Involved In UV-damage Excision Repair Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation	Membrane
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