PLPP6 and PRLR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLPP6	PRLR
Description		phospholipid phosphatase 6	prolactin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endosome Lumen Receptor Complex
	Molecular Function	Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Lyase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Isoprenoid Diphosphate Phosphatase Activity	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Protein Kinase Binding Cytokine Binding Metal Ion Binding
	Biological Process	Immune System Process Lipid Metabolic Process Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Protein Prenylation Geranyl Diphosphate Metabolic Process Innate Immune Response Farnesyl Diphosphate Catabolic Process Phospholipid Dephosphorylation Geranylgeranyl Diphosphate Catabolic Process Positive Regulation Of Neutrophil Activation	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Response To Bacterium Cytokine-mediated Signaling Pathway Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Positive Regulation Of B Cell Proliferation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Mammary Gland Epithelium Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Cold-induced Thermogenesis
Pathways		Cholesterol biosynthesis	Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Lonapegsomatropin
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Chronotype ( 30696823) DHEAS levels ( 34748635) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		57 interacting genes: AMIGO1 AQP6 AQP8 BTN2A1 BTNL9 C16orf92 CD79A CIAO2A CLDN15 CLDN9 CLEC4M CLN5 COMT CREB3L1 EBP FAM174A FAM209A FAM210B FKBP7 FNDC9 FXYD3 GJB5 GKN1 GORAB GPX8 HSH2D IL10RA IL13RA2 KASH5 LAYN LDLRAD1 MMGT1 MS4A3 MUC1 NCR3LG1 PDGFRA PDZK1IP1 PHACTR3 PRLR PVR RETREG3 RNF170 RNF5 SEC11C SHISAL1 SIGLEC12 SLC7A14 SMAGP SOCS4 SSMEM1 STX1A SYNE4 SYNPR TMEM106C TMIE TNFRSF10D VSIR	20 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 INSIG2 JAK2 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		403313	5618
HPRD ID		17397	01457
Ensembl ID		ENSG00000205808	ENSG00000113494
Uniprot IDs		Q8IY26	P16471
PDB IDs			1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?		Membrane	Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Binding Protein Modification Process Regulation Of Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Endosome Lumen Growth Hormone Receptor Signaling Pathway Intracellular Signal Transduction Vesicle Positive Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Phosphorylation-dependent Protein Binding Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Prolactin Receptor Binding Positive Regulation Of Immune System Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Signal Transduction Cytokine Receptor Binding Developmental Process Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Sequestering Activity
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