PLPP6 and IL13RA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLPP6	IL13RA2
Description		phospholipid phosphatase 6	interleukin 13 receptor subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Lyase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Isoprenoid Diphosphate Phosphatase Activity	Cytokine Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Immune System Process Lipid Metabolic Process Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Protein Prenylation Geranyl Diphosphate Metabolic Process Innate Immune Response Farnesyl Diphosphate Catabolic Process Phospholipid Dephosphorylation Geranylgeranyl Diphosphate Catabolic Process Positive Regulation Of Neutrophil Activation	Negative Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Transforming Growth Factor Beta1 Production Interleukin-13-mediated Signaling Pathway Negative Regulation Of Mast Cell Degranulation
Pathways		Cholesterol biosynthesis	Interleukin-4 and Interleukin-13 signaling
Drugs			AER001
Diseases
GWAS
Interacting Genes		57 interacting genes: AMIGO1 AQP6 AQP8 BTN2A1 BTNL9 C16orf92 CD79A CIAO2A CLDN15 CLDN9 CLEC4M CLN5 COMT CREB3L1 EBP FAM174A FAM209A FAM210B FKBP7 FNDC9 FXYD3 GJB5 GKN1 GORAB GPX8 HSH2D IL10RA IL13RA2 KASH5 LAYN LDLRAD1 MMGT1 MS4A3 MUC1 NCR3LG1 PDGFRA PDZK1IP1 PHACTR3 PRLR PVR RETREG3 RNF170 RNF5 SEC11C SHISAL1 SIGLEC12 SLC7A14 SMAGP SOCS4 SSMEM1 STX1A SYNE4 SYNPR TMEM106C TMIE TNFRSF10D VSIR	17 interacting genes: AKT1 BAG4 BRMS1 CASP8 EGFR ERBB2 ESR2 IGF1R IL13 IL4 IL4R NOTCH2 PALB2 PAX2 PIK3CA PLPP6 RB1CC1
Entrez ID		403313	3598
HPRD ID		17397	02132
Ensembl ID		ENSG00000205808	ENSG00000123496
Uniprot IDs		Q8IY26	Q14627
PDB IDs			3LB6
Enriched GO Terms of Interacting Partners?		Membrane	Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Multicellular Organismal Process Immune System Process Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process ERBB Signaling Pathway Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Animal Organ Development Positive Regulation Of Immune System Process Regulation Of Developmental Process Positive Regulation Of Cold-induced Thermogenesis Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Immune System Process Response To Lipid Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Cell Migration Positive Regulation Of Cell Differentiation Leukocyte Activation Apoptotic Process Regulation Of Cold-induced Thermogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Locomotion Cell Death Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Developmental Process Defense Response Interleukin-4-mediated Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Activation
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