PLPP6 and SIGLEC12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLPP6	SIGLEC12
Description		phospholipid phosphatase 6	sialic acid binding Ig like lectin 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Lyase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Isoprenoid Diphosphate Phosphatase Activity	Protein Binding Carbohydrate Binding Sialic Acid Binding
	Biological Process	Immune System Process Lipid Metabolic Process Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Protein Prenylation Geranyl Diphosphate Metabolic Process Innate Immune Response Farnesyl Diphosphate Catabolic Process Phospholipid Dephosphorylation Geranylgeranyl Diphosphate Catabolic Process Positive Regulation Of Neutrophil Activation	Cell Adhesion
Pathways		Cholesterol biosynthesis	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS
Interacting Genes		57 interacting genes: AMIGO1 AQP6 AQP8 BTN2A1 BTNL9 C16orf92 CD79A CIAO2A CLDN15 CLDN9 CLEC4M CLN5 COMT CREB3L1 EBP FAM174A FAM209A FAM210B FKBP7 FNDC9 FXYD3 GJB5 GKN1 GORAB GPX8 HSH2D IL10RA IL13RA2 KASH5 LAYN LDLRAD1 MMGT1 MS4A3 MUC1 NCR3LG1 PDGFRA PDZK1IP1 PHACTR3 PRLR PVR RETREG3 RNF170 RNF5 SEC11C SHISAL1 SIGLEC12 SLC7A14 SMAGP SOCS4 SSMEM1 STX1A SYNE4 SYNPR TMEM106C TMIE TNFRSF10D VSIR	17 interacting genes: ACSF2 ADIPOQ ATP5PF CDIPT CLEC4G CMAS CTSA DNAJC30 IL1RL1 MGST1 PLPP6 PLPPR2 PTCH1 PTPN11 PTPN6 TMPRSS4 YIPF1
Entrez ID		403313	89858
HPRD ID		17397	16195
Ensembl ID		ENSG00000205808	ENSG00000254521
Uniprot IDs		Q8IY26	Q96PQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Regulation Of Neutrophil Activation Phosphate-containing Compound Metabolic Process Dephosphorylation Organophosphate Metabolic Process Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Adaptive Immune Response Negative Regulation Of Cell-cell Adhesion Negative Regulation Of T Cell Proliferation Neutrophil Activation Involved In Immune Response Brain Development Phosphatidate Phosphatase Activity Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Immune System Process Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Adhesion Platelet Formation Megakaryocyte Development Positive Regulation Of Viral Life Cycle Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Transport Negative Regulation Of T Cell Activation Negative Regulation Of Cytokine Production Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Regulation Of Cell Activation Lipid Modification Cellular Response To Lipid Hydroperoxide Negative Regulation Of Cell Population Proliferation Neural Plate Axis Specification Regulation Of Cholesterol Efflux Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cholesterol Transport Reproductive Structure Development Cytokine-mediated Signaling Pathway Regulation Of T Cell Proliferation Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Cell Activation Negative Regulation Of Lymphocyte Activation Regulation Of Tumor Necrosis Factor Production T Cell Costimulation Regulation Of Cytokine-mediated Signaling Pathway Epididymis Development Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Positive Regulation Of D-glucose Import Positive Regulation Of D-glucose Transmembrane Transport
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