PLPP6 and CLEC4M

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLPP6	CLEC4M
Description		phospholipid phosphatase 6	C-type lectin domain family 4 member M
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Host Cell
	Molecular Function	Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Lyase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Isoprenoid Diphosphate Phosphatase Activity	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding ICAM-3 Receptor Activity Signaling Receptor Activity Pattern Recognition Receptor Activity Peptide Antigen Binding Virion Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Immune System Process Lipid Metabolic Process Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Protein Prenylation Geranyl Diphosphate Metabolic Process Innate Immune Response Farnesyl Diphosphate Catabolic Process Phospholipid Dephosphorylation Geranylgeranyl Diphosphate Catabolic Process Positive Regulation Of Neutrophil Activation	Adaptive Immune Response Immune System Process Endocytosis Immune Response Leukocyte Cell-cell Adhesion Cell-cell Recognition Virion Attachment To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Viral Genome Replication Antigen Processing And Presentation Intracellular Signal Transduction Innate Immune Response Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Peptide Antigen Transport Intracellular Transport Of Virus
Pathways		Cholesterol biosynthesis	RSV-host interactions
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Lipoprotein (a) levels ( 33730874) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) vWF levels ( 30586737) White blood cell count ( 32888494)
Interacting Genes		57 interacting genes: AMIGO1 AQP6 AQP8 BTN2A1 BTNL9 C16orf92 CD79A CIAO2A CLDN15 CLDN9 CLEC4M CLN5 COMT CREB3L1 EBP FAM174A FAM209A FAM210B FKBP7 FNDC9 FXYD3 GJB5 GKN1 GORAB GPX8 HSH2D IL10RA IL13RA2 KASH5 LAYN LDLRAD1 MMGT1 MS4A3 MUC1 NCR3LG1 PDGFRA PDZK1IP1 PHACTR3 PRLR PVR RETREG3 RNF170 RNF5 SEC11C SHISAL1 SIGLEC12 SLC7A14 SMAGP SOCS4 SSMEM1 STX1A SYNE4 SYNPR TMEM106C TMIE TNFRSF10D VSIR	6 interacting genes: CD209 ICAM3 IFT20 ITGAM PLPP6 SNCA
Entrez ID		403313	10332
HPRD ID		17397	12060
Ensembl ID		ENSG00000205808	ENSG00000104938
Uniprot IDs		Q8IY26	A0A7P0MMK7 Q9H2X3
PDB IDs			1K9J 1SL6 1XAR 1XPH 3JQH 8RCY
Enriched GO Terms of Interacting Partners?		Membrane	Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Endocytosis Import Into Cell Regulation Of Dopamine Metabolic Process Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Vesicle-mediated Transport Positive Regulation Of Reactive Oxygen Species Metabolic Process Macrophage Activation Positive Regulation Of Exocytosis Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission B Cell Adhesion Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Cell-cell Adhesion Response To External Biotic Stimulus Integrin AlphaM-beta2 Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Opsin Transport Intraciliary Transport Particle Regulation Of Reactive Oxygen Species Metabolic Process Innate Immune Response Positive Regulation Of Neutrophil Degranulation Response To Curcumin Vertebrate Eye-specific Patterning Myeloid Leukocyte Activation Regulation Of Immune System Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Regulation Of Cell Activation Negative Regulation Of Chaperone-mediated Autophagy Peptide Antigen Transport Kinociliary Basal Body Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Integrin Binding Positive Regulation Of Microglial Cell Mediated Cytotoxicity Complement-mediated Synapse Pruning Regulation Of Serotonin Uptake Opsin Binding Receptor-mediated Endocytosis
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