PLPP6 and AQP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLPP6	AQP8
Description		phospholipid phosphatase 6	aquaporin 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane	Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Smooth Endoplasmic Reticulum Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Smooth Endoplasmic Reticulum Membrane Brush Border Membrane Mitochondrial Membrane Apical Part Of Cell Intracellular Canaliculus Intracellular Vesicle
	Molecular Function	Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Lyase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Isoprenoid Diphosphate Phosphatase Activity	Protein Binding Ammonium Channel Activity Water Channel Activity Methylammonium Channel Activity Urea Channel Activity Channel Activity
	Biological Process	Immune System Process Lipid Metabolic Process Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Protein Prenylation Geranyl Diphosphate Metabolic Process Innate Immune Response Farnesyl Diphosphate Catabolic Process Phospholipid Dephosphorylation Geranylgeranyl Diphosphate Catabolic Process Positive Regulation Of Neutrophil Activation	Water Transport Urea Transport Methylammonium Transport One-carbon Compound Transport B Cell Differentiation Transepithelial Water Transport Regulation Of Cholesterol Biosynthetic Process Transmembrane Transport Cellular Response To CAMP Urea Transmembrane Transport Ammonium Transmembrane Transport Methylammonium Transmembrane Transport Hydrogen Peroxide Transmembrane Transport Ammonium Import Across Plasma Membrane Cellular Detoxification
Pathways		Cholesterol biosynthesis	Detoxification of Reactive Oxygen Species Passive transport by Aquaporins Developmental Lineage of Pancreatic Acinar Cells
Drugs
Diseases
GWAS			Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856)
Interacting Genes		57 interacting genes: AMIGO1 AQP6 AQP8 BTN2A1 BTNL9 C16orf92 CD79A CIAO2A CLDN15 CLDN9 CLEC4M CLN5 COMT CREB3L1 EBP FAM174A FAM209A FAM210B FKBP7 FNDC9 FXYD3 GJB5 GKN1 GORAB GPX8 HSH2D IL10RA IL13RA2 KASH5 LAYN LDLRAD1 MMGT1 MS4A3 MUC1 NCR3LG1 PDGFRA PDZK1IP1 PHACTR3 PRLR PVR RETREG3 RNF170 RNF5 SEC11C SHISAL1 SIGLEC12 SLC7A14 SMAGP SOCS4 SSMEM1 STX1A SYNE4 SYNPR TMEM106C TMIE TNFRSF10D VSIR	6 interacting genes: CYBC1 PLP2 PLPP6 SERP1 STX12 TMEM120B
Entrez ID		403313	343
HPRD ID		17397	04778
Ensembl ID		ENSG00000205808	ENSG00000103375
Uniprot IDs		Q8IY26	O94778
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Endoplasmic Reticulum Membrane Nuclear Inner Membrane Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Endoplasmic Reticulum Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Chemokine Binding Postsynaptic Recycling Endosome Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion Respiratory Burst Involved In Defense Response Respiratory Burst After Phagocytosis Lipid Phosphatase Activity Farnesyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Protein Prenylation Lysophosphatidic Acid Phosphatase Activity Regulation Of Neutrophil Activation Monoatomic Ion Transmembrane Transporter Activity Membrane Regulation Of Growth Hormone Secretion Phosphatidate Phosphatase Activity
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