PLPP6 and CLN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLPP6	CLN5
Description		phospholipid phosphatase 6	CLN5 lysosomal BMP synthase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane	Lysosome Lysosomal Membrane Vacuolar Lumen Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Lyase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Isoprenoid Diphosphate Phosphatase Activity	Protein Binding D-mannose Binding Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Long-chain Fatty Acyl-CoA Hydrolase Activity Bis(monoacylglycero)phosphate Synthase Activity
	Biological Process	Immune System Process Lipid Metabolic Process Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Protein Prenylation Geranyl Diphosphate Metabolic Process Innate Immune Response Farnesyl Diphosphate Catabolic Process Phospholipid Dephosphorylation Geranylgeranyl Diphosphate Catabolic Process Positive Regulation Of Neutrophil Activation	Signal Peptide Processing Lysosome Organization Lysosomal Lumen Acidification Brain Development Visual Perception Neurogenesis Protein Catabolic Process Retrograde Transport, Endosome To Golgi Neuron Maturation Glycosylation Positive Regulation Of GTP Binding
Pathways		Cholesterol biosynthesis
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS			Blood protein levels ( 30072576) Major depressive disorder ( 34099189) Morning vs. evening chronotype ( 26835600) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		57 interacting genes: AMIGO1 AQP6 AQP8 BTN2A1 BTNL9 C16orf92 CD79A CIAO2A CLDN15 CLDN9 CLEC4M CLN5 COMT CREB3L1 EBP FAM174A FAM209A FAM210B FKBP7 FNDC9 FXYD3 GJB5 GKN1 GORAB GPX8 HSH2D IL10RA IL13RA2 KASH5 LAYN LDLRAD1 MMGT1 MS4A3 MUC1 NCR3LG1 PDGFRA PDZK1IP1 PHACTR3 PRLR PVR RETREG3 RNF170 RNF5 SEC11C SHISAL1 SIGLEC12 SLC7A14 SMAGP SOCS4 SSMEM1 STX1A SYNE4 SYNPR TMEM106C TMIE TNFRSF10D VSIR	9 interacting genes: FDFT1 GPR152 IGF2 INS-IGF2 OGT PLPP6 SLC41A1 SLC41A2 TMEM31
Entrez ID		403313	1203
HPRD ID		17397	07619
Ensembl ID		ENSG00000205808	ENSG00000102805
Uniprot IDs		Q8IY26	A0A1B0GTR6 O75503
PDB IDs			6R99
Enriched GO Terms of Interacting Partners?		Membrane	Farnesyl Diphosphate Metabolic Process Inorganic Cation Transmembrane Transporter Activity Magnesium Ion Transport Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Monoatomic Cation Transmembrane Transporter Activity Insulin Receptor Binding Cholesterol Biosynthetic Process Sterol Biosynthetic Process Squalene Synthase [NAD(P)H] Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Terpenoid Metabolic Process Steroid Biosynthetic Process Nickel Cation Transport Magnesium:sodium Antiporter Activity Regulation Of Glucose Metabolic Process Isoprenoid Metabolic Process Cholesterol Metabolic Process Hormone Activity Protein O-acetylglucosaminyltransferase Activity Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Sterol Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Embryonic Placenta Morphogenesis Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Intracellular Magnesium Ion Homeostasis Cellular Response To Magnesium Ion Lipid Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity Regulation Of Skeletal Muscle Tissue Growth Carbon Catabolite Regulation Of Transcription Lysophosphatidic Acid Phosphatase Activity Cobalt Ion Transport Regulation Of Transcription By Glucose Protein Prenylation Exocrine Pancreas Development NSL Complex Regulation Of Neutrophil Activation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?