PLPP6 and SMAGP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLPP6	SMAGP
Description		phospholipid phosphatase 6	small cell adhesion glycoprotein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane	Nucleoplasm Plasma Membrane Membrane Cell Junction Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Lyase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Isoprenoid Diphosphate Phosphatase Activity	Protein Binding
	Biological Process	Immune System Process Lipid Metabolic Process Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Protein Prenylation Geranyl Diphosphate Metabolic Process Innate Immune Response Farnesyl Diphosphate Catabolic Process Phospholipid Dephosphorylation Geranylgeranyl Diphosphate Catabolic Process Positive Regulation Of Neutrophil Activation
Pathways		Cholesterol biosynthesis
Drugs
Diseases
GWAS			Mean platelet volume ( 32888494)
Interacting Genes		57 interacting genes: AMIGO1 AQP6 AQP8 BTN2A1 BTNL9 C16orf92 CD79A CIAO2A CLDN15 CLDN9 CLEC4M CLN5 COMT CREB3L1 EBP FAM174A FAM209A FAM210B FKBP7 FNDC9 FXYD3 GJB5 GKN1 GORAB GPX8 HSH2D IL10RA IL13RA2 KASH5 LAYN LDLRAD1 MMGT1 MS4A3 MUC1 NCR3LG1 PDGFRA PDZK1IP1 PHACTR3 PRLR PVR RETREG3 RNF170 RNF5 SEC11C SHISAL1 SIGLEC12 SLC7A14 SMAGP SOCS4 SSMEM1 STX1A SYNE4 SYNPR TMEM106C TMIE TNFRSF10D VSIR	40 interacting genes: APH1A AQP6 ARL13B ATP1B3 C2orf74 CD53 EBP ERGIC3 FAM209A FFAR2 GPX8 IL3RA JAGN1 OPRD1 OPRM1 PIGP PLPP6 PLPPR2 REEP4 RNASEK SERINC2 SGTA SLC10A6 SLC16A7 SLC71A2 SPACA1 SUSD3 TLCD4 TMEM106C TMEM14B TMEM205 TMEM234 TMEM31 TMEM45B TMEM51 TMEM80 TMPPE TMX2 UPK2 YWHAE
Entrez ID		403313	57228
HPRD ID		17397	14256
Ensembl ID		ENSG00000205808	ENSG00000170545
Uniprot IDs		Q8IY26	Q0VAQ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Membrane G Protein-coupled Opioid Receptor Activity Endoplasmic Reticulum G Protein-coupled Opioid Receptor Signaling Pathway
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