STRBP and MAP4

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		STRBP	MAP4
Description		spermatid perinuclear RNA binding protein	microtubule associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Manchette Nucleus Cytoplasm Microtubule Cytoskeleton	Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Axon Ciliary Basal Body Neuron Projection Mitotic Spindle
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding Microtubule Binding Tubulin Binding	RNA Binding Structural Molecule Activity Protein Binding Microtubule Binding Tubulin Binding Microtubule Stabilizing Activity
	Biological Process	Spermatogenesis Spermatid Development Mechanosensory Behavior Cell Differentiation Cell Motility	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Neuron Projection Development Microtubule Polymerization Microtubule Sliding Establishment Of Spindle Orientation Cell Division Cilium Disassembly Negative Regulation Of Non-motile Cilium Assembly
Pathways
Drugs			Paclitaxel Docetaxel Artenimol
Diseases
GWAS		Birth weight ( 27680694) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 31217584 31562340) Lymphocyte count ( 32888494)	Blood pressure ( 21909110) Body mass index and systole blood pressure (pairwise) ( 33619380) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 27618452 27841878 28739976) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean arterial pressure ( 27618448) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27618452 27841878 28739976 30578418)
Interacting Genes		59 interacting genes: ADARB1 ARNT CAMK2G DAB1 EIF2AK2 HMGXB4 LRRK2 MAP4 MIR1-1 MIR1-2 MIR106A MIR122 MIR128-2 MIR138-1 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR199A1 MIR199A2 MIR19A MIR200A MIR200B MIR200C MIR214 MIR221 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR429 MIR7-1 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G NEIL3 RBFOX1 RBPMS RBPMS2 STAU1 THAP1 ZMAT4 ZNF346	26 interacting genes: CCNB1 CDC42 CDK1 CEBPA CLASP1 ENO2 ERBIN GSK3B IL7R LDLR MARK1 MARK4 NEIL3 NOP58 NR1I3 POT1 RNF10 RXRB RXRG SNTA1 SRPK2 STRBP SUMO2 TERF1 TUBB UBC
Entrez ID		55342	4134
HPRD ID		10257	01141
Ensembl ID		ENSG00000165209	ENSG00000047849
Uniprot IDs		A0A0S2Z5K8 Q96SI9 V9HWK4	A0A804HKE7 E7EVA0 P27816
PDB IDs		2DMY
Enriched GO Terms of Interacting Partners?		Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Gene Expression Negative Regulation Of Cell Motility Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Negative Regulation Of Locomotion RNA Destabilization Positive Regulation Of MRNA Catabolic Process Extracellular Vesicle Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Negative Regulation Of Angiogenesis Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Translation Regulation Of Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration	Positive Regulation Of Macromolecule Metabolic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cyclin B1-CDK1 Complex Positive Regulation Of Organelle Organization Tau-protein Kinase Activity Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Organelle Organization Positive Regulation Of Metabolic Process Cytoskeleton Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Postsynapse Shelterin Complex Microtubule Cytoskeleton Organization Cell Division Positive Regulation Of Biosynthetic Process Tau Protein Binding Positive Regulation Of Protein Localization To Centrosome Retinoic Acid-responsive Element Binding Mitotic Spindle Mitotic Cell Cycle Phase Transition Cytoskeleton Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Ventricular Cardiac Muscle Cell Development Cell Cycle Phase Transition Establishment Or Maintenance Of Cell Polarity G-rich Strand Telomeric DNA Binding Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Cilium Disassembly Telomeric Loop Disassembly Nucleoplasm Response To Lipid Microtubule-based Process Regulation Of Protein Localization To Centrosome Telomere Capping Protein Phosphorylation Glutamatergic Synapse Protein Serine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Protein Tag Activity Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cell Cycle G1/S Phase Transition
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