MAP2K7 and LPXN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MAP2K7	LPXN
Description		mitogen-activated protein kinase kinase 7	leupaxin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity	Transcription Coregulator Activity Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Response To Heat Response To UV Response To Wounding Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Telomere Maintenance Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Senescence Regulation Of Motor Neuron Apoptotic Process	Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs		Pimasertib
Diseases
GWAS		Appendicular lean mass ( 33097823) Fasting insulin ( 34059833) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 23823483) Type 2 diabetes ( 30297969 32499647)	Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		33 interacting genes: ARR3 ATF4 CEBPA CFLAR CNKSR1 DUSP19 DUSP22 GADD45B JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2	33 interacting genes: AGXT AQP1 GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 LMO3 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RNF214 RUNX1T1 SFI1 TGFB1 TNS2 TXLNB VCL ZNF175 ZNF426
Entrez ID		5609	9404
HPRD ID		04309	05651
Ensembl ID		ENSG00000076984	ENSG00000110031
Uniprot IDs		B4DV95 O14733	B7Z5P7 O60711
PDB IDs		2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR 6YFZ 6YG0 6YG1 6YG2 6YG3 6YG4 6YG5 6YG6 6YG7 6YZ4 7CBX 7OVI 7OVJ 7OVK 7OVL 7OVM 7OVN	1X3H 4XEF 4XEK 4XEV
Enriched GO Terms of Interacting Partners?		MAPK Cascade MAP Kinase Kinase Kinase Activity Intracellular Signaling Cassette JNK Cascade Regulation Of MAPK Cascade Protein Serine Kinase Activity Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Kinase Activity Regulation Of JNK Cascade Signal Transduction Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphorylation Positive Regulation Of Signal Transduction Protein Kinase Binding Cytoplasm JUN Kinase Kinase Kinase Activity ATP Binding Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Programmed Cell Death Transferase Activity MAP-kinase Scaffold Activity Cellular Response To Stress MAP Kinase Activity Positive Regulation Of Programmed Cell Death Fc-epsilon Receptor Signaling Pathway Cellular Response To Oxidative Stress P38MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of P38MAPK Cascade Nucleotide Binding Positive Regulation Of Apoptotic Process Regulation Of Immune System Process Cellular Response To Chemical Stress Mitogen-activated Protein Kinase Kinase Binding Protein Modification Process Integrated Stress Response Signaling	Response To Dexamethasone Focal Adhesion Positive Regulation Of Fibroblast Migration Developmental Growth Developmental Growth Involved In Morphogenesis Anchoring Junction Cellular Response To Dexamethasone Stimulus Cellular Response To Lipid Cellular Response To Oxygen-containing Compound Multicellular Organismal-level Homeostasis Positive Regulation Of Mononuclear Cell Migration Regulation Of Fibroblast Migration Response To Fluid Shear Stress Developmental Cell Growth Response To Lipid Signal Complex Assembly Regulation Of Cell-matrix Adhesion Response To Glucocorticoid Regulation Of Fat Cell Differentiation Cellular Response To Glucocorticoid Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Corticosteroid Regulation Of RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Corticosteroid Stimulus Anatomical Structure Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Focal Adhesion Assembly Regulation Of RNA Biosynthetic Process Response To Growth Factor Response To Transforming Growth Factor Beta Negative Regulation Of Nucleobase-containing Compound Metabolic Process ERBB Signaling Pathway Regulation Of Cell-substrate Junction Organization MAP Kinase Activity Regulation Of Primary Metabolic Process Regulation Of Cytoskeleton Organization Cellular Response To Steroid Hormone Stimulus Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Projection Extension Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Migration Positive Regulation Of Catabolic Process Response To Wounding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?