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MAP2K7 and DUSP19
Number of citations of the paper that reports this interaction (PMID
11959861
)
5
Data Source:
HPRD
(in vitro, in vivo)
MAP2K7
DUSP19
Gene Name
mitogen-activated protein kinase kinase 7
dual specificity phosphatase 19
Image
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Cytoplasm
Cytosol
Cytoplasm
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
JUN Kinase Kinase Activity
Enzyme Binding
Protein Kinase Binding
Protein Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Protein Tyrosine Phosphatase Activity
Protein Kinase Inhibitor Activity
MAP-kinase Scaffold Activity
Protein Tyrosine/threonine Phosphatase Activity
JUN Kinase Phosphatase Activity
Protein Kinase Activator Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Biological Process
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Response To Osmotic Stress
Signal Transduction
JNK Cascade
Activation Of JUN Kinase Activity
Pathogenesis
Response To Heat
Response To UV
Peptidyl-tyrosine Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Response To Tumor Necrosis Factor
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Innate Immune Response
Stress-activated MAPK Cascade
Cellular Response To Sorbitol
Inactivation Of MAPK Activity
Negative Regulation Of Protein Kinase Activity
Protein Dephosphorylation
JNK Cascade
Peptidyl-tyrosine Dephosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Negative Regulation Of JUN Kinase Activity
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of JNK Cascade
Positive Regulation Of JNK Cascade
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
Uptake and actions of bacterial toxins
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Uptake and function of anthrax toxins
Innate Immune System
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Oxidative Stress Induced Senescence
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions
30 interactors:
ARR3
ATF4
CFLAR
CNKSR1
DUSP19
DUSP22
GADD45B
JUN
LPXN
LRRK2
MAP3K1
MAP3K11
MAP3K12
MAP3K13
MAP3K2
MAP3K3
MAP3K4
MAP3K5
MAPK1
MAPK14
MAPK8
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPK9
RPL30
TRAF6
TRIB1
VRK2
ZAK
4 interactors:
ALAS1
MAP2K7
MAP3K5
MAPK9
Entrez ID
5609
142679
HPRD ID
04309
13254
Ensembl ID
ENSG00000076984
ENSG00000162999
Uniprot IDs
O14733
Q8WTR2
PDB IDs
2DYL
3S4E
Enriched GO Terms of Interacting Partners
?
MAPK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Signal Transduction By Phosphorylation
JNK Cascade
Regulation Of MAPK Cascade
Regulation Of Protein Phosphorylation
Regulation Of Phosphorylation
Regulation Of Stress-activated MAPK Cascade
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Activation Of MAPKK Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of MAP Kinase Activity
Regulation Of Protein Metabolic Process
Regulation Of JNK Cascade
Positive Regulation Of Transferase Activity
Positive Regulation Of Phosphorylation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Protein Phosphorylation
Activation Of Protein Kinase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Protein Serine/threonine Kinase Activity
Activation Of MAPK Activity
Regulation Of Signaling
Positive Regulation Of MAP Kinase Activity
Cellular Response To Stress
Positive Regulation Of JNK Cascade
Regulation Of JUN Kinase Activity
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Metabolic Process
Signal Transduction
Protein Phosphorylation
JNK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Regulation Of JNK Cascade
Regulation Of Stress-activated MAPK Cascade
MAPK Cascade
Signal Transduction By Phosphorylation
Activation Of JUN Kinase Activity
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Neuron Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Cell Death
Regulation Of MAPK Cascade
Regulation Of JUN Kinase Activity
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Protein Phosphorylation
Zymogen Activation
Toll-like Receptor Signaling Pathway
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Positive Regulation Of JNK Cascade
Positive Regulation Of Cysteine-type Endopeptidase Activity
Response To Tumor Necrosis Factor
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Endopeptidase Activity
Positive Regulation Of Phosphorylation
Innate Immune Response-activating Signal Transduction
Response To UV
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Activation Of MAPK Activity
Activation Of Innate Immune Response
Positive Regulation Of Protein Modification Process
Positive Regulation Of Peptidase Activity
Apoptotic Process
Programmed Cell Death
Cell Death
Tagcloud
?
bag1
bcl2l2
bctis
ccna2
comprehend
ctsb
deregulations
fgf1
fosl1
gabrp
gsn
hnepi
id2
il6r
itgb4
klf5
klk5
microdissected
ngfb
ngfr
ontological
pappa
plau
scgb1d2
scgb2a1
serpinb5
serpine1
thbs1
thbs2
Tagcloud (Difference)
?
bag1
bcl2l2
bctis
ccna2
comprehend
ctsb
deregulations
fgf1
fosl1
gabrp
gsn
hnepi
id2
il6r
itgb4
klf5
klk5
microdissected
ngfb
ngfr
ontological
pappa
plau
scgb1d2
scgb2a1
serpinb5
serpine1
thbs1
thbs2
Tagcloud (Intersection)
?