MAP2K7 and MAP3K13

Number of citations of the paper that reports this interaction (PubMedID 11726277)
0

Data Source:
BioGRID (enzymatic study)

		MAP2K7	MAP3K13
Description		mitogen-activated protein kinase kinase 7	mitogen-activated protein kinase kinase kinase 13
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding IkappaB Kinase Complex Binding Protein Serine Kinase Activity
	Biological Process	Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Response To Heat Response To UV Response To Wounding Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Telomere Maintenance Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Senescence Regulation Of Motor Neuron Apoptotic Process	Protein Phosphorylation JNK Cascade Positive Regulation Of Neuron Maturation Intracellular Signal Transduction Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs		Pimasertib	Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Fasting insulin ( 34059833) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 23823483) Type 2 diabetes ( 30297969 32499647)	Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822) Neonatal white matter microstructure ( 33009551)
Interacting Genes		33 interacting genes: ARR3 ATF4 CEBPA CFLAR CNKSR1 DUSP19 DUSP22 GADD45B JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2	8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25
Entrez ID		5609	9175
HPRD ID		04309	05372
Ensembl ID		ENSG00000076984	ENSG00000073803
Uniprot IDs		B4DV95 O14733	O43283
PDB IDs		2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR 6YFZ 6YG0 6YG1 6YG2 6YG3 6YG4 6YG5 6YG6 6YG7 6YZ4 7CBX 7OVI 7OVJ 7OVK 7OVL 7OVM 7OVN
Enriched GO Terms of Interacting Partners?		MAPK Cascade MAP Kinase Kinase Kinase Activity Intracellular Signaling Cassette JNK Cascade Regulation Of MAPK Cascade Protein Serine Kinase Activity Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Kinase Activity Regulation Of JNK Cascade Signal Transduction Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphorylation Positive Regulation Of Signal Transduction Protein Kinase Binding Cytoplasm JUN Kinase Kinase Kinase Activity ATP Binding Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Programmed Cell Death Transferase Activity MAP-kinase Scaffold Activity Cellular Response To Stress MAP Kinase Activity Positive Regulation Of Programmed Cell Death Fc-epsilon Receptor Signaling Pathway Cellular Response To Oxidative Stress P38MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of P38MAPK Cascade Nucleotide Binding Positive Regulation Of Apoptotic Process Regulation Of Immune System Process Cellular Response To Chemical Stress Mitogen-activated Protein Kinase Kinase Binding Protein Modification Process Integrated Stress Response Signaling	Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Negative Regulation Of Phosphate Metabolic Process Response To Cytokine Response To Peptide Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway MAPK Cascade Negative Regulation Of Cytokine Production Involved In Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Regulation Of RNA Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction JNK Cascade MRNA Transcription Lactoylglutathione Lyase Activity Antigen Processing And Presentation Of Peptide Antigen Regulation Of Canonical NF-kappaB Signal Transduction Response To Lipid Dentate Gyrus Mossy Fiber NADH-dependent Peroxiredoxin Activity Regulation Of Nucleobase-containing Compound Metabolic Process Cytosol Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Immune Response-activating Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Monocyte Aggregation
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