MAP2K7 and MAP3K13

Number of citations of the paper that reports this interaction (PMID 11726277)
4

Data Source:
BioGRID (enzymatic study)

		MAP2K7	MAP3K13
Gene Name		mitogen-activated protein kinase kinase 7	mitogen-activated protein kinase kinase kinase 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cytosol	IkappaB Kinase Complex Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding JUN Kinase Kinase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Pathogenesis Response To Heat Response To UV Peptidyl-tyrosine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Stress-activated MAPK Cascade Cellular Response To Sorbitol	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Uptake and actions of bacterial toxins MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Uptake and function of anthrax toxins Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling
Drugs
Diseases
GWAS			Airflow obstruction ( 22837378)
Protein-Protein Interactions		30 interactors: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 RPL30 TRAF6 TRIB1 VRK2 ZAK	7 interactors: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3
Entrez ID		5609	9175
HPRD ID		04309	05372
Ensembl ID		ENSG00000076984	ENSG00000073803
Uniprot IDs		O14733	O43283
PDB IDs		2DYL
Enriched GO Terms of Interacting Partners?		MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signal Transduction By Phosphorylation JNK Cascade Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Stress-activated MAPK Cascade Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Activation Of MAPKK Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Protein Metabolic Process Regulation Of JNK Cascade Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Activation Of MAPK Activity Regulation Of Signaling Positive Regulation Of MAP Kinase Activity Cellular Response To Stress Positive Regulation Of JNK Cascade Regulation Of JUN Kinase Activity Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Metabolic Process Signal Transduction Protein Phosphorylation	Regulation Of Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Response To Cytokine Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Organic Substance Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of JUN Kinase Activity JNK Cascade Defense Response Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Peptidyl-cysteine Oxidation Response To Tumor Necrosis Factor Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of JNK Cascade Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Sorbitol Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Stress-activated MAPK Cascade Intracellular Receptor Signaling Pathway Regulation Of Immune Response
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
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