MAP2K7 and GADD45B

Number of citations of the paper that reports this interaction (PMID 14743220)
87

Data Source:
HPRD (in vivo, in vitro)

		MAP2K7	GADD45B
Gene Name		mitogen-activated protein kinase kinase 7	growth arrest and DNA-damage-inducible, beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding JUN Kinase Kinase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding	Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Pathogenesis Response To Heat Response To UV Peptidyl-tyrosine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Stress-activated MAPK Cascade Cellular Response To Sorbitol	Activation Of MAPKKK Activity Activation Of MAPKK Activity Negative Regulation Of Protein Kinase Activity Apoptotic Process Response To Stress Multicellular Organismal Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of P38MAPK Cascade
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Uptake and actions of bacterial toxins MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Uptake and function of anthrax toxins Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 RPL30 TRAF6 TRIB1 VRK2 ZAK	13 interactors: CCNB1 CDK1 CDKN1A ESR1 GADD45G GADD45GIP1 MAP2K7 MAP3K4 MAP3K5 PCNA PPARA PPARD PPARG
Entrez ID		5609	4616
HPRD ID		04309	05382
Ensembl ID		ENSG00000076984	ENSG00000099860
Uniprot IDs		O14733	O75293
PDB IDs		2DYL
Enriched GO Terms of Interacting Partners?		MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signal Transduction By Phosphorylation JNK Cascade Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Stress-activated MAPK Cascade Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Activation Of MAPKK Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Protein Metabolic Process Regulation Of JNK Cascade Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Activation Of MAPK Activity Regulation Of Signaling Positive Regulation Of MAP Kinase Activity Cellular Response To Stress Positive Regulation Of JNK Cascade Regulation Of JUN Kinase Activity Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Metabolic Process Signal Transduction Protein Phosphorylation	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Activation Of MAPKK Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Lipid Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Heart Development Positive Regulation Of Protein Modification Process Regulation Of Fibroblast Proliferation Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Apoptotic Process Cellular Response To Stress Programmed Cell Death Cell Death Death Positive Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Hormone-mediated Signaling Pathway Tissue Development Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Stress Response To Organic Substance Activation Of MAPK Activity Cellular Response To Organic Substance G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Cyclic Compound Positive Regulation Of Signal Transduction Regulation Of JNK Cascade Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Lipid Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing
Tagcloud (Intersection) ?