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MAP2K7 and MAP3K2
Number of citations of the paper that reports this interaction (PMID
9372971
)
24
Data Source:
HPRD
(in vivo, in vitro)
MAP2K7
MAP3K2
Gene Name
mitogen-activated protein kinase kinase 7
mitogen-activated protein kinase kinase kinase 2
Image
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Cytoplasm
Cytosol
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
JUN Kinase Kinase Activity
Enzyme Binding
Protein Kinase Binding
Protein Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Metal Ion Binding
Biological Process
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Response To Osmotic Stress
Signal Transduction
JNK Cascade
Activation Of JUN Kinase Activity
Pathogenesis
Response To Heat
Response To UV
Peptidyl-tyrosine Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Response To Tumor Necrosis Factor
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Innate Immune Response
Stress-activated MAPK Cascade
Cellular Response To Sorbitol
Activation Of MAPKK Activity
Activation Of MAPK Activity
Protein Phosphorylation
Activation Of JUN Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Cellular Response To Mechanical Stimulus
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
Uptake and actions of bacterial toxins
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Uptake and function of anthrax toxins
Innate Immune System
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Oxidative Stress Induced Senescence
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions
30 interactors:
ARR3
ATF4
CFLAR
CNKSR1
DUSP19
DUSP22
GADD45B
JUN
LPXN
LRRK2
MAP3K1
MAP3K11
MAP3K12
MAP3K13
MAP3K2
MAP3K3
MAP3K4
MAP3K5
MAPK1
MAPK14
MAPK8
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPK9
RPL30
TRAF6
TRIB1
VRK2
ZAK
25 interactors:
BIRC2
IKBKG
MAP2K3
MAP2K4
MAP2K5
MAP2K7
MAP3K3
MAP3K5
MAPK8
NEDD4
NEDD4L
NFKBIA
PIBF1
PKN2
SH2D2A
SMURF1
STAMBP
STUB1
UBC
USP2
WNK1
XIAP
YWHAE
YWHAG
YWHAZ
Entrez ID
5609
10746
HPRD ID
04309
10068
Ensembl ID
ENSG00000076984
ENSG00000169967
Uniprot IDs
O14733
Q9Y2U5
PDB IDs
2DYL
2CU1
2NPT
Enriched GO Terms of Interacting Partners
?
MAPK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Signal Transduction By Phosphorylation
JNK Cascade
Regulation Of MAPK Cascade
Regulation Of Protein Phosphorylation
Regulation Of Phosphorylation
Regulation Of Stress-activated MAPK Cascade
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Activation Of MAPKK Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of MAP Kinase Activity
Regulation Of Protein Metabolic Process
Regulation Of JNK Cascade
Positive Regulation Of Transferase Activity
Positive Regulation Of Phosphorylation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Protein Phosphorylation
Activation Of Protein Kinase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Protein Serine/threonine Kinase Activity
Activation Of MAPK Activity
Regulation Of Signaling
Positive Regulation Of MAP Kinase Activity
Cellular Response To Stress
Positive Regulation Of JNK Cascade
Regulation Of JUN Kinase Activity
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Metabolic Process
Signal Transduction
Protein Phosphorylation
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Signal Transduction
Intracellular Signal Transduction
Apoptotic Process
Toll-like Receptor 5 Signaling Pathway
Programmed Cell Death
Toll-like Receptor 10 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Signaling
Toll-like Receptor Signaling Pathway
Cell Death
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Death
Cell Communication
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
Activation Of MAPK Activity
Activation Of Innate Immune Response
Positive Regulation Of Protein Metabolic Process
Regulation Of Innate Immune Response
Cellular Response To Stimulus
Signal Transduction By Phosphorylation
Positive Regulation Of Innate Immune Response
Response To Stimulus
Regulation Of Apoptotic Process
Cellular Protein Modification Process
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Regulation Of Cell Death
Positive Regulation Of MAP Kinase Activity
Activation Of Protein Kinase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
JNK Cascade
Regulation Of MAP Kinase Activity
Positive Regulation Of Protein Modification Process
Cellular Response To Stress
Regulation Of Catalytic Activity
Tagcloud
?
bag1
bcl2l2
bctis
ccna2
comprehend
ctsb
deregulations
fgf1
fosl1
gabrp
gsn
hnepi
id2
il6r
itgb4
klf5
klk5
microdissected
ngfb
ngfr
ontological
pappa
plau
scgb1d2
scgb2a1
serpinb5
serpine1
thbs1
thbs2
Tagcloud (Difference)
?
bag1
bcl2l2
bctis
ccna2
comprehend
ctsb
deregulations
fgf1
fosl1
gabrp
gsn
hnepi
id2
il6r
itgb4
klf5
klk5
microdissected
ngfb
ngfr
ontological
pappa
plau
scgb1d2
scgb2a1
serpinb5
serpine1
thbs1
thbs2
Tagcloud (Intersection)
?