MAP2K7 and MAP3K2

Number of citations of the paper that reports this interaction (PubMedID 10713157)
61

Data Source:
HPRD (in vivo, in vitro)

		MAP2K7	MAP3K2
Description		mitogen-activated protein kinase kinase 7	mitogen-activated protein kinase kinase kinase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Response To Heat Response To UV Response To Wounding Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Telomere Maintenance Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Senescence Regulation Of Motor Neuron Apoptotic Process	MAPK Cascade Intracellular Signal Transduction Cellular Response To Mechanical Stimulus
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs		Pimasertib	Bosutinib Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Fasting insulin ( 34059833) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 23823483) Type 2 diabetes ( 30297969 32499647)	Protein C levels ( 28082259)
Interacting Genes		33 interacting genes: ARR3 ATF4 CEBPA CFLAR CNKSR1 DUSP19 DUSP22 GADD45B JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2	27 interacting genes: BIRC2 CTNNB1 IKBKG ITCH LATS1 MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NFKBIA PIBF1 PKN2 SH2D2A SMURF1 SMYD3 STAMBP STUB1 USP2 WNK1 XIAP YAP1 YWHAE YWHAG YWHAZ
Entrez ID		5609	10746
HPRD ID		04309	10068
Ensembl ID		ENSG00000076984	ENSG00000169967
Uniprot IDs		B4DV95 O14733	Q9Y2U5
PDB IDs		2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR 6YFZ 6YG0 6YG1 6YG2 6YG3 6YG4 6YG5 6YG6 6YG7 6YZ4 7CBX 7OVI 7OVJ 7OVK 7OVL 7OVM 7OVN	2CU1 2NPT 5EX0 5HQ8 6LDV 6LDW 6LDX 6LDY
Enriched GO Terms of Interacting Partners?		MAPK Cascade MAP Kinase Kinase Kinase Activity Intracellular Signaling Cassette JNK Cascade Regulation Of MAPK Cascade Protein Serine Kinase Activity Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Kinase Activity Regulation Of JNK Cascade Signal Transduction Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphorylation Positive Regulation Of Signal Transduction Protein Kinase Binding Cytoplasm JUN Kinase Kinase Kinase Activity ATP Binding Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Programmed Cell Death Transferase Activity MAP-kinase Scaffold Activity Cellular Response To Stress MAP Kinase Activity Positive Regulation Of Programmed Cell Death Fc-epsilon Receptor Signaling Pathway Cellular Response To Oxidative Stress P38MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of P38MAPK Cascade Nucleotide Binding Positive Regulation Of Apoptotic Process Regulation Of Immune System Process Cellular Response To Chemical Stress Mitogen-activated Protein Kinase Kinase Binding Protein Modification Process Integrated Stress Response Signaling	Intracellular Signal Transduction MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Stress Signal Transduction Protein Modification Process Positive Regulation Of Protein Metabolic Process Cytosol Protein Polyubiquitination Cytoplasm Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Transferase Activity Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Post-translational Protein Modification Protein Serine Kinase Activity Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway MAP Kinase Kinase Activity Protein Phosphatase Binding Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Immune Response Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Protein Modification Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cellular Senescence Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Protein Kinase Activity Stress-activated Protein Kinase Signaling Cascade Phosphoserine Residue Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Modification-dependent Protein Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
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