CDC42BPB and AMN

		CDC42BPB	AMN
Description		CDC42 binding protein kinase beta	amnion associated transmembrane protein
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Lamellipodium Cell Leading Edge Actomyosin Cell Projection Extracellular Exosome Anchoring Junction	Extracellular Region Extracellular Space Endosome Plasma Membrane Clathrin-coated Pit Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Microvillus Membrane Protein-containing Complex Receptor Complex Apical Part Of Cell Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity	Signaling Receptor Binding Protein Binding Cargo Receptor Activity
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Migration Actin Cytoskeleton Organization Actomyosin Structure Organization	Receptor-mediated Endocytosis Intracellular Protein Localization Cobalamin Metabolic Process Protein Transport Cobalamin Transport Golgi To Plasma Membrane Protein Transport Renal Protein Absorption
Pathways		CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle	Defective AMN causes MGA1 Defective CUBN causes MGA1 HDL clearance Uptake of dietary cobalamins into enterocytes
Drugs			Hydroxocobalamin
Diseases
GWAS		A body shape index ( 34021172) Body mass index ( 26426971) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for body mass index ( 34021172)	Body mass index ( 26426971)
Interacting Genes		7 interacting genes: CDC42 MAP2K5 PPM1A PPP2CA PYGM RIPK1 WDR4	1 interacting genes: STAMBP
Entrez ID		9578	81693
HPRD ID		08516	09314
Ensembl ID		ENSG00000198752	ENSG00000166126
Uniprot IDs		H0YLY0 Q86XZ8 Q9Y5S2	B3KP64 Q9BXJ7
PDB IDs		3QFV 3TKU 4UAK 4UAL 5OTE 5OTF	6GJE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Hippo Signaling Cellular Response To Fluid Shear Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intracellular Signal Transduction Regulation Of Hippo Signaling Tau Protein Binding Response To Fluid Shear Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apical Part Of Cell GBD Domain Binding Storage Vacuole Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine Kinase Activity Cellular Response To Growth Factor Stimulus Protein Dephosphorylation Response To Growth Factor Protein Serine/threonine Phosphatase Activity Regulation Of Canonical NF-kappaB Signal Transduction RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Interleukin-8 Production ERK5 Cascade Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Protein Serine/threonine Kinase Activity Nucleotide Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Glycogen Phosphorylase Activity Positive Regulation Of Interleukin-6-mediated Signaling Pathway Death Domain Binding TRNA (guanine-N7)-methylation Apolipoprotein A-I Receptor Binding Intracellular Signal Transduction Neuropilin Signaling Pathway Regulation Of Cell Cycle Cytosol N-terminal Protein Myristoylation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Mitotic Cell Cycle Protein Kinase Activity
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