CDC42BPB and KLC1

		CDC42BPB	KLC1
Description		CDC42 binding protein kinase beta	kinesin light chain 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Lamellipodium Cell Leading Edge Actomyosin Cell Projection Extracellular Exosome Anchoring Junction	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity	Cytoskeletal Motor Activity Protein Binding Kinesin Binding
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Migration Actin Cytoskeleton Organization Actomyosin Structure Organization	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly
Pathways		CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins
Drugs
Diseases
GWAS		A body shape index ( 34021172) Body mass index ( 26426971) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for body mass index ( 34021172)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: CDC42 MAP2K5 PPM1A PPP2CA PYGM RIPK1 WDR4	29 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB
Entrez ID		9578	3831
HPRD ID		08516	02489
Ensembl ID		ENSG00000198752	ENSG00000126214
Uniprot IDs		H0YLY0 Q86XZ8 Q9Y5S2	F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2
PDB IDs		3QFV 3TKU 4UAK 4UAL 5OTE 5OTF	3NF1 5OJ8 7AI4 7AIE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Hippo Signaling Cellular Response To Fluid Shear Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intracellular Signal Transduction Regulation Of Hippo Signaling Tau Protein Binding Response To Fluid Shear Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apical Part Of Cell GBD Domain Binding Storage Vacuole Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine Kinase Activity Cellular Response To Growth Factor Stimulus Protein Dephosphorylation Response To Growth Factor Protein Serine/threonine Phosphatase Activity Regulation Of Canonical NF-kappaB Signal Transduction RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Interleukin-8 Production ERK5 Cascade Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Protein Serine/threonine Kinase Activity Nucleotide Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Glycogen Phosphorylase Activity Positive Regulation Of Interleukin-6-mediated Signaling Pathway Death Domain Binding TRNA (guanine-N7)-methylation Apolipoprotein A-I Receptor Binding Intracellular Signal Transduction Neuropilin Signaling Pathway Regulation Of Cell Cycle Cytosol N-terminal Protein Myristoylation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Mitotic Cell Cycle Protein Kinase Activity	Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade
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