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NFKB2
Gene Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Bcl3/NF-kappaB2 Complex
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Coactivator Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Toll-like Receptor Signaling Pathway
Follicular Dendritic Cell Differentiation
Germinal Center Formation
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Extracellular Matrix Organization
Positive Regulation Of Type I Interferon Production
Response To Cytokine
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Spleen Development
Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
RIP-mediated NFkB activation via ZBP1
Toll Like Receptor TLR6:TLR2 Cascade
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
ZBP1(DAI) mediated induction of type I IFNs
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Innate Immune System
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
Cytokine Signaling in Immune system
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Signaling by Interleukins
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Interleukin-1 processing
TRAF6 mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-protein Interactions
35 interactors:
BCL3
BTRC
CHUK
DDX3X
DPF2
EPS8
GLG1
GTF2I
HDAC4
HDAC5
IKBKB
IKBKG
MAP3K14
MAP3K8
MEN1
NFKB1
NFKBIA
NFKBIB
NFKBIE
NFKBIZ
NKRF
NR3C1
NR5A1
PSMD11
REL
RELA
RELB
RPL30
RPL6
RPS13
SIN3A
SP1
TNIP2
TSC22D3
USP2
Entrez ID
4791
HPRD ID
01239
Ensembl ID
ENSG00000077150
Uniprot IDs
Q00653
PDB IDs
1A3Q
2D96
3DO7
Enriched GO Terms of Interacting Partners
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I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Immune System Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Toll-like Receptor 3 Signaling Pathway
Regulation Of Gene Expression
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Type I Interferon Production
Activation Of Innate Immune Response
Gene Expression
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Toll-like Receptor 5 Signaling Pathway
RNA Metabolic Process
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Type I Interferon Production
Toll-like Receptor Signaling Pathway
Transcription, DNA-templated
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
MyD88-independent Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Pattern Recognition Receptor Signaling Pathway
Cellular Macromolecule Biosynthetic Process
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
NIK/NF-kappaB Signaling
Macromolecule Biosynthetic Process
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Innate Immune Response
Positive Regulation Of Cytokine Production
Negative Regulation Of Gene Expression
Intracellular Signal Transduction
Tagcloud
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arrangement
bcl
cbcl
cbcls
clonal
clonality
cls
ctcl
ctcls
cutaneous
deletions
extranodal
germline
hodgkin
ig
lymphoid
lymphomas
lyt
malignancies
neoplasias
nodal
oncogenes
pathogenetic
rearrangement
rearrangements
southern
tal
tcr
undetectable