NFKB2 and DPF2

Number of citations of the paper that reports this interaction (PMID 20460684)
8

Data Source:
BioGRID (pull down)

		NFKB2	DPF2
Gene Name		nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	D4, zinc and double PHD fingers family 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Bcl3/NF-kappaB2 Complex	Nuclear Chromatin Nucleoplasm Cytoplasm Centrosome Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway Follicular Dendritic Cell Differentiation Germinal Center Formation MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Apoptotic Signaling Pathway
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Signaling by Interleukins Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 processing TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2	14 interactors: ESRRA ESRRB ESRRG FHL2 HIST1H3A HIST3H3 LDOC1 LNX1 NFKB2 REL RELB SMARCB1 UPF2 ZNF212
Entrez ID		4791	5977
HPRD ID		01239	03394
Ensembl ID		ENSG00000077150	ENSG00000133884
Uniprot IDs		Q00653	B4DT58 J3KMZ8 Q92785
PDB IDs		1A3Q 2D96 3DO7	3IUF
Enriched GO Terms of Interacting Partners?		I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Immune System Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 3 Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Gene Expression Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway RNA Metabolic Process Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Transcription, DNA-templated TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Pattern Recognition Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Macromolecule Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Negative Regulation Of Gene Expression Intracellular Signal Transduction	Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process NIK/NF-kappaB Signaling Intracellular Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Metabolic Process Response To Organic Substance DNA-templated Transcription, Initiation Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Follicular Dendritic Cell Differentiation Trophectodermal Cell Proliferation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Blastocyst Development
Tagcloud ?		arrangement bcl cbcl cbcls clonal clonality cls ctcl ctcls cutaneous deletions extranodal germline hodgkin ig lymphoid lymphomas lyt malignancies neoplasias nodal oncogenes pathogenetic rearrangement rearrangements southern tal tcr undetectable	1alpha acetylated androgen associating baf45d biogenesis coactivator coactivators converted derepressed enhances err erralpha fingers hdac1 hela myoblast peroxisome pgc phd proliferator purification recognizing repressive repressor stably steroid superfamily transactivation
Tagcloud (Difference) ?		arrangement bcl cbcl cbcls clonal clonality cls ctcl ctcls cutaneous deletions extranodal germline hodgkin ig lymphoid lymphomas lyt malignancies neoplasias nodal oncogenes pathogenetic rearrangement rearrangements southern tal tcr undetectable	1alpha acetylated androgen associating baf45d biogenesis coactivator coactivators converted derepressed enhances err erralpha fingers hdac1 hela myoblast peroxisome pgc phd proliferator purification recognizing repressive repressor stably steroid superfamily transactivation
Tagcloud (Intersection) ?