NFKB2 and DDX3X

Number of citations of the paper that reports this interaction (PubMedID 14743216)
0

Data Source:
HPRD (in vitro)

		NFKB2	DDX3X
Description		nuclear factor kappa B subunit 2	DEAD-box helicase 3 X-linked
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol I-kappaB/NF-kappaB Complex Bcl3/NF-kappaB2 Complex	Extracellular Region Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Eukaryotic Translation Initiation Factor 3 Complex Cytoskeleton Plasma Membrane Cytoplasmic Stress Granule Membrane Cytosolic Small Ribosomal Subunit Lamellipodium Cell Leading Edge Secretory Granule Lumen Cell Projection P Granule Canonical Inflammasome Complex Extracellular Exosome NLRP3 Inflammasome Complex Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding GTPase Activity Helicase Activity Protein Binding ATP Binding Transcription Factor Binding Poly(A) Binding Eukaryotic Initiation Factor 4E Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Signaling Adaptor Activity RNA Stem-loop Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding CTPase Activity Protein Serine/threonine Kinase Activator Activity Cadherin Binding MRNA 5'-UTR Binding
	Biological Process	Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction Extracellular Matrix Organization Response To Lipopolysaccharide Response To Cytokine Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Intracellular Signaling Cassette	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Translational Initiation Regulation Of Translation Apoptotic Process Chromosome Segregation Gamete Generation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Stress Granule Assembly Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Ribosome Biogenesis Cytosolic Ribosome Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation Lipid Homeostasis Positive Regulation Of Mitochondrial Translation Cellular Response To Arsenic-containing Substance Cellular Response To Osmotic Stress Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein K63-linked Ubiquitination Protein Localization To Cytoplasmic Stress Granule Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection Regulation of PD-L1(CD274) transcription	Neutrophil degranulation
Drugs		Sulfasalazine Donepezil Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Terpinen-4-ol Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Metabolite levels ( 23823483) Refractive error ( 32231278) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Refractive error ( 32231278)
Interacting Genes		36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2	101 interacting genes: ANXA1 APBB1 CEBPA CRYAA CSNK2A1 DSCR9 DUX4 ESR1 HNF4A IKBKE IL7R LINC01232 LINC01554 MAVS MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 NFKB2 NUP62 OGT PIN1 SREK1 SRPK2 SUMO2 TRIM25 USP7 USP9X WBP4 XPO1 YWHAQ ZNF512B
Entrez ID		4791	1654
HPRD ID		01239	02154
Ensembl ID		ENSG00000077150	ENSG00000215301
Uniprot IDs		Q00653	A0A2R8YDT5 A0A2R8YFS5 O00571
PDB IDs		1A3Q 2D96 3DO7 4OT9 5ZMC 7CLI 7VUP 7VUQ 7W7L 8G8Q 8G8S	2I4I 2JGN 3JRV 4O2C 4O2E 4O2F 4PX9 4PXA 5E7I 5E7J 5E7M 6CZ5 6O5F 7LIU 8SSW
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Canonical NF-kappaB Signal Transduction Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Inflammatory Response Regulation Of Gene Expression Immune System Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Defense Response Intracellular Signaling Cassette Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Nucleus Response To External Biotic Stimulus Immune Response-activating Signaling Pathway Negative Regulation Of Biosynthetic Process Cytoplasm Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Nucleoplasm Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of Defense Response NF-kappaB Complex Pattern Recognition Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Translation Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Communication Regulation Of MRNA Metabolic Process
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