GSDMB and IGFBP2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		GSDMB	IGFBP2
Name		gasdermin B	insulin like growth factor binding protein 2
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Extracellular Region Extracellular Space Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Cardiolipin Binding	Protein Phosphatase Inhibitor Activity Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Signaling Receptor Inhibitor Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Receptor Ligand Inhibitor Activity
	Biological Process	Programmed Cell Death Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Killing By Host Of Symbiont Cells Transmembrane Transport Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death	Osteoblast Differentiation Female Pregnancy Response To Nutrient Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Positive Regulation Of Activated T Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Negative Regulation Of Osteoblast Differentiation Response To Steroid Hormone Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		None	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
GWAS		Adult asthma ( 30787307 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 29273806 28461288 20860503 21804549 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 29273806 34022066 24241537 31036433 27611488 30929738 ) Asthma (time to onset) ( 27130862 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atrial fibrillation ( 30061737 ) Bronchial hyperresponsiveness in asthma ( 27439200 ) Cervical cancer ( 23817570 ) Childhood asthma with severe exacerbations ( 33328473 ) Crohn's disease ( 28067908 ) Dermatomyositis or juvenile dermatomyositis ( 26362759 ) Feeling miserable ( 29500382 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) IgM levels ( 28628107 ) Inflammatory bowel disease ( 23128233 28067908 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Monocyte percentage of white cells ( 27863252 ) Primary biliary cholangitis ( 23000144 20639880 30643196 ) Primary biliary cirrhosis ( 22961000 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Self-reported allergy ( 23817569 ) Serum alkaline phosphatase levels ( 33339817 ) Subcutaneous adipose tissue ( 27918534 ) Systemic lupus erythematosus ( 26502338 ) Systemic sclerosis ( 31672989 28314753 ) Type 1 diabetes ( 30659077 25751624 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 21738480 32888494 )	Glomerular filtration rate (creatinine) ( 28452372 ) Gut microbiota alpha diversity (Chao1 index) ( 33208821 ) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821 ) Mitral valve prolapse ( 26301497 ) Thyroid stimulating hormone levels ( 25743335 ) Type 2 diabetes ( 26818947 )
Novel Interactors		9 novel interactors: CDK12 CWC25 DHRS11 FNDC8 GGNBP2 MRM1 MYO19 NLE1 SLFN12	3 novel interactors: BMPR2 CASP10 RPS6KA1
Interacting Genes		8 interacting genes: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1	6 interacting genes: GSDMB IGF1 IGF2 INO80B KLK2 TF
Entrez ID		55876	3485
HPRD ID		17082	00898
Ensembl ID		ENSG00000073605	ENSG00000115457
Uniprot IDs		Q8TAX9	C9JMY1 P18065
PDB IDs		5TIB 5TJ2 5TJ4 7WJQ 8EFP 8ET1 8ET2 8GTJ 8GTK 8GTN	2H7T
GO Terms Enriched among Interactors		Serine-type Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Peptidase Inhibitor Activity	Lung Vasculature Development Positive Regulation Of Growth Exocrine Pancreas Development Osteoblast Differentiation Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Developmental Growth Insulin Receptor Binding Epithelial Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cellular Component Organization Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Regulation Of Glycogen Metabolic Process Blood Vessel Remodeling Regulation Of Activated T Cell Proliferation Lung Alveolus Development Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Vasculature Development Extracellular Space Proteoglycan Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Developmental Growth Basal Plasma Membrane Platelet Alpha Granule Lumen Negative Regulation Of Oocyte Development Clathrin-coated Pit Negative Regulation Of Muscle Cell Differentiation Striated Muscle Cell Differentiation Positive Regulation Of Osteoblast Differentiation Insulin Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Tissue Remodeling Proteoglycan Metabolic Process Positive Regulation Of Cell Activation Regulation Of Cell Growth Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Positive Regulation Of Trophectodermal Cell Proliferation Regulation Of Organ Growth Cytotoxic T Cell Pyroptotic Cell Death Positive Regulation Of RNA Metabolic Process Regulation Of Glucose Metabolic Process Secretory Granule