GSDMB and CWC25

Data Source: HiPPIP (Novel)

		GSDMB	CWC25
Name		gasdermin B	CWC25 spliceosome associated protein
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex Nuclear Speck U2-type Catalytic Step 1 Spliceosome
	Molecular Function	Phosphatidylserine Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Cardiolipin Binding	Protein Binding
	Biological Process	Programmed Cell Death Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Killing By Host Of Symbiont Cells Transmembrane Transport Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		None	mRNA Splicing - Major Pathway
GWAS		Adult asthma ( 30787307 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 29273806 28461288 20860503 21804549 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 29273806 34022066 24241537 31036433 27611488 30929738 ) Asthma (time to onset) ( 27130862 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atrial fibrillation ( 30061737 ) Bronchial hyperresponsiveness in asthma ( 27439200 ) Cervical cancer ( 23817570 ) Childhood asthma with severe exacerbations ( 33328473 ) Crohn's disease ( 28067908 ) Dermatomyositis or juvenile dermatomyositis ( 26362759 ) Feeling miserable ( 29500382 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) IgM levels ( 28628107 ) Inflammatory bowel disease ( 23128233 28067908 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Monocyte percentage of white cells ( 27863252 ) Primary biliary cholangitis ( 23000144 20639880 30643196 ) Primary biliary cirrhosis ( 22961000 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Self-reported allergy ( 23817569 ) Serum alkaline phosphatase levels ( 33339817 ) Subcutaneous adipose tissue ( 27918534 ) Systemic lupus erythematosus ( 26502338 ) Systemic sclerosis ( 31672989 28314753 ) Type 1 diabetes ( 30659077 25751624 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 21738480 32888494 )	Intraocular pressure ( 29617998 )
Novel Interactors		9 novel interactors: CDK12 CWC25 DHRS11 FNDC8 GGNBP2 MRM1 MYO19 NLE1 SLFN12	1 novel interactors: GSDMB
Interacting Genes		8 interacting genes: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1	7 interacting genes: CCDC85B FMR1 KRT34 LAMC3 MDM2 OGT TRIM21
Entrez ID		55876	54883
HPRD ID		17082	07892
Ensembl ID		ENSG00000073605	ENSG00000273559
Uniprot IDs		Q8TAX9	Q9NXE8
PDB IDs		5TIB 5TJ2 5TJ4 7WJQ 8EFP 8ET1 8ET2 8GTJ 8GTK 8GTN	5YZG 6ZYM 8I0W
GO Terms Enriched among Interactors		Serine-type Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Peptidase Inhibitor Activity	Pyroptotic Inflammatory Response Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Viral Life Cycle Negative Regulation Of Protein Metabolic Process Stress Granule Assembly Cellular Response To Nutrient Negative Regulation Of Translational Initiation Membraneless Organelle Assembly Positive Regulation Of Viral Process Positive Regulation Of Intracellular Transport Of Viral Material Response To Formaldehyde Protein Autoubiquitination Cellular Response To Vitamin B1 Protein Destabilization Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Protein Catabolic Process Regulation Of Receptor Internalization Regulation Of Proteolysis Cytoplasmic Stress Granule Negative Regulation Of Post-translational Protein Modification Dendritic Filopodium Histone H3 Reader Activity Cytotoxic T Cell Pyroptotic Cell Death Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Long-term Synaptic Depression Regulation Of Viral Life Cycle Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Translational Initiation Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Viral Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process NEDD8 Ligase Activity Response To Actinomycin D Negative Regulation Of Proteolysis Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Inflammatory Response Negative Regulation Of Protein Deubiquitination Response To Nutrient RNA Strand Annealing Activity Regulation Of Neuronal Action Potential