GSDMB and MYO19

		GSDMB	MYO19
Description		gasdermin B	myosin XIX
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Actin Cytoskeleton Membrane Myosin Complex
	Molecular Function	Phosphatidylserine Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Cardiolipin Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding ATP Binding Cytoskeletal Protein Binding ATP Hydrolysis Activity Myosin Light Chain Binding Actin Filament Binding Plus-end Directed Microfilament Motor Activity
	Biological Process	Programmed Cell Death Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Killing By Host Of Symbiont Cells Transmembrane Transport Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death	Endocytosis Actin Filament Organization Regulation Of Cytokinesis Mitochondrion Migration Along Actin Filament Establishment Of Mitochondrion Localization Regulation Of Mitochondrial Fission Mitocytosis
Pathways			RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 29273806 28461288 20860503 21804549) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 29273806 34022066 24241537 31036433 27611488 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Cervical cancer ( 23817570) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 28067908) Dermatomyositis or juvenile dermatomyositis ( 26362759) Feeling miserable ( 29500382) Fractional exhaled nitric oxide (childhood) ( 24315451) IgM levels ( 28628107) Inflammatory bowel disease ( 23128233 28067908) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Monocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33339817) Subcutaneous adipose tissue ( 27918534) Systemic lupus erythematosus ( 26502338) Systemic sclerosis ( 31672989 28314753) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908) White blood cell count ( 21738480 32888494)	Body mass index ( 26426971 28552196 29273807) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31015462 31152163)
Interacting Genes		8 interacting genes: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1	1 interacting genes: DHX16
Entrez ID		55876	80179
HPRD ID		17082	10107
Ensembl ID		ENSG00000073605	ENSG00000278259
Uniprot IDs		Q8TAX9	B4E218 B7Z1T7 Q96H55
PDB IDs		5TIB 5TJ2 5TJ4 7WJQ 8EFP 8ET1 8ET2 8GTJ 8GTK 8GTN
Enriched GO Terms of Interacting Partners?		Serine-type Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Peptidase Inhibitor Activity	Cytotoxic T Cell Pyroptotic Cell Death ATP-dependent Activity, Acting On RNA Defense Response To Other Organism Defense Response To Symbiont Pyroptotic Cell Death Wide Pore Channel Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Defense Response Pattern Recognition Receptor Activity Response To Other Organism Response To External Biotic Stimulus U2-type Precatalytic Spliceosome Biological Process Involved In Interaction With Symbiont Phosphatidylinositol-4-phosphate Binding Pyroptotic Inflammatory Response Killing By Host Of Symbiont Cells Phosphatidylserine Binding Antiviral Innate Immune Response RNA Helicase Activity Phosphatidylinositol-4,5-bisphosphate Binding Defense Response To Gram-negative Bacterium Ubiquitin Binding Helicase Activity Killing Of Cells Of Another Organism Phospholipid Binding
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