GSDMB

Name	gasdermin B
Structure
Novel Interactors	9 novel interactors: CDK12 CWC25 DHRS11 FNDC8 GGNBP2 MRM1 MYO19 NLE1 SLFN12
Interactors	8 interactors: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Phosphatidylserine Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Cardiolipin Binding
	Biological Process	Programmed Cell Death Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Killing By Host Of Symbiont Cells Transmembrane Transport Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death
GWAS	Adult asthma ( 30787307 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 29273806 28461288 20860503 21804549 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 29273806 34022066 24241537 31036433 27611488 30929738 ) Asthma (time to onset) ( 27130862 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atrial fibrillation ( 30061737 ) Bronchial hyperresponsiveness in asthma ( 27439200 ) Cervical cancer ( 23817570 ) Childhood asthma with severe exacerbations ( 33328473 ) Crohn's disease ( 28067908 ) Dermatomyositis or juvenile dermatomyositis ( 26362759 ) Feeling miserable ( 29500382 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) IgM levels ( 28628107 ) Inflammatory bowel disease ( 23128233 28067908 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Monocyte percentage of white cells ( 27863252 ) Primary biliary cholangitis ( 23000144 20639880 30643196 ) Primary biliary cirrhosis ( 22961000 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Self-reported allergy ( 23817569 ) Serum alkaline phosphatase levels ( 33339817 ) Subcutaneous adipose tissue ( 27918534 ) Systemic lupus erythematosus ( 26502338 ) Systemic sclerosis ( 31672989 28314753 ) Type 1 diabetes ( 30659077 25751624 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 21738480 32888494 )
Entrez ID	55876
HPRD ID	17082
Ensembl ID	ENSG00000073605
Uniprot IDs	Q8TAX9
PDB IDs	5TIB 5TJ2 5TJ4 7WJQ 8EFP 8ET1 8ET2 8GTJ 8GTK 8GTN
GO Terms Enriched among Interactors ?	Serine-type Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Peptidase Inhibitor Activity