GSDMB and GGNBP2

Data Source: HiPPIP (Novel)

		GSDMB	GGNBP2
Name		gasdermin B	gametogenetin binding protein 2
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Nucleus Cytoplasm Cytoplasmic Vesicle
	Molecular Function	Phosphatidylserine Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Cardiolipin Binding	None
	Biological Process	Programmed Cell Death Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Killing By Host Of Symbiont Cells Transmembrane Transport Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death	Spermatogenesis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Cell Differentiation Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Negative Regulation Of Receptor Signaling Pathway Via STAT
GWAS		Adult asthma ( 30787307 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 29273806 28461288 20860503 21804549 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 29273806 34022066 24241537 31036433 27611488 30929738 ) Asthma (time to onset) ( 27130862 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atrial fibrillation ( 30061737 ) Bronchial hyperresponsiveness in asthma ( 27439200 ) Cervical cancer ( 23817570 ) Childhood asthma with severe exacerbations ( 33328473 ) Crohn's disease ( 28067908 ) Dermatomyositis or juvenile dermatomyositis ( 26362759 ) Feeling miserable ( 29500382 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) IgM levels ( 28628107 ) Inflammatory bowel disease ( 23128233 28067908 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Monocyte percentage of white cells ( 27863252 ) Primary biliary cholangitis ( 23000144 20639880 30643196 ) Primary biliary cirrhosis ( 22961000 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Self-reported allergy ( 23817569 ) Serum alkaline phosphatase levels ( 33339817 ) Subcutaneous adipose tissue ( 27918534 ) Systemic lupus erythematosus ( 26502338 ) Systemic sclerosis ( 31672989 28314753 ) Type 1 diabetes ( 30659077 25751624 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 21738480 32888494 )	Adult body size ( 32376654 ) Body mass index ( 25673413 28892062 ) Body size at age 10 ( 32376654 ) Intelligence (MTAG) ( 29326435 )
Novel Interactors		9 novel interactors: CDK12 CWC25 DHRS11 FNDC8 GGNBP2 MRM1 MYO19 NLE1 SLFN12	1 novel interactors: GSDMB
Interacting Genes		8 interacting genes: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1	1 interacting genes: GGN
Entrez ID		55876	79893
HPRD ID		17082	18337
Ensembl ID		ENSG00000073605	ENSG00000278311
Uniprot IDs		Q8TAX9	Q9H3C7
PDB IDs		5TIB 5TJ2 5TJ4 7WJQ 8EFP 8ET1 8ET2 8GTJ 8GTK 8GTN	8BFJ
GO Terms Enriched among Interactors		Serine-type Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Peptidase Inhibitor Activity	Cytotoxic T Cell Pyroptotic Cell Death Wide Pore Channel Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Pyroptotic Cell Death Phosphatidylinositol-4-phosphate Binding Killing By Host Of Symbiont Cells Biological Process Involved In Interaction With Symbiont Pyroptotic Inflammatory Response Phosphatidylserine Binding