GSDMB and DHRS11

		GSDMB	DHRS11
Description		gasdermin B	dehydrogenase/reductase 11
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Extracellular Region
	Molecular Function	Phosphatidylserine Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Cardiolipin Binding	Nucleotide Binding 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	Programmed Cell Death Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Killing By Host Of Symbiont Cells Transmembrane Transport Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Steroid Metabolic Process
Pathways
Drugs			Nicotinamide adenine dinucleotide phosphate
Diseases
GWAS		Adult asthma ( 30787307) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 29273806 28461288 20860503 21804549) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 29273806 34022066 24241537 31036433 27611488 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Cervical cancer ( 23817570) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 28067908) Dermatomyositis or juvenile dermatomyositis ( 26362759) Feeling miserable ( 29500382) Fractional exhaled nitric oxide (childhood) ( 24315451) IgM levels ( 28628107) Inflammatory bowel disease ( 23128233 28067908) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Monocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33339817) Subcutaneous adipose tissue ( 27918534) Systemic lupus erythematosus ( 26502338) Systemic sclerosis ( 31672989 28314753) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908) White blood cell count ( 21738480 32888494)	Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		8 interacting genes: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1	1 interacting genes: DLG3
Entrez ID		55876	79154
HPRD ID		17082	08331
Ensembl ID		ENSG00000073605	ENSG00000278535
Uniprot IDs		Q8TAX9	Q6UWP2
PDB IDs		5TIB 5TJ2 5TJ4 7WJQ 8EFP 8ET1 8ET2 8GTJ 8GTK 8GTN	1XG5
Enriched GO Terms of Interacting Partners?		Serine-type Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Peptidase Inhibitor Activity	Cytotoxic T Cell Pyroptotic Cell Death Phosphatase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Planar Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Ionotropic Glutamate Receptor Binding Receptor Clustering Receptor Localization To Synapse AMPA Glutamate Receptor Complex Biological Process Involved In Interaction With Symbiont Phosphatidylinositol-4-phosphate Binding Pyroptotic Inflammatory Response Pyroptotic Cell Death Wide Pore Channel Activity Killing By Host Of Symbiont Cells Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Protein Localization To Synapse Phosphatidylserine Binding Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Phosphatidylinositol-4,5-bisphosphate Binding Neuromuscular Junction Protein Localization To Cell Junction Defense Response To Gram-negative Bacterium Postsynaptic Density Membrane Kinase Binding Bicellular Tight Junction Killing Of Cells Of Another Organism Phospholipid Binding
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