VPS11 and FUT1

		VPS11	FUT1
Description		VPS11 core subunit of CORVET and HOPS complexes	fucosyltransferase 1 (H blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Vesicle Tethering Complex	Golgi Membrane Extracellular Space Golgi Apparatus Plasma Membrane Membrane Golgi Cisterna Membrane
	Molecular Function	Nucleotide Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Galactoside 2-alpha-L-fucosyltransferase Activity Fucosyltransferase Activity Transferase Activity Glycosyltransferase Activity Alpha-(1,2)-fucosyltransferase Activity
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Catabolic Process Organelle Fusion Regulation Of Organelle Assembly Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport	Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Carbohydrate Metabolic Process Protein Glycosylation Lipid Metabolic Process Glycosphingolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Triglyceride Catabolic Process Response To Activity Olfactory Bulb Development Regulation Of Cell Adhesion Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Fucosylation L-fucose Catabolic Process Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Xenobiotic Stimulus Endothelial Cell Apoptotic Process Positive Regulation Of Sprouting Angiogenesis Response To Methionine Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		SARS-CoV-2 modulates autophagy	ABO blood group biosynthesis Glycosphingolipid biosynthesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Bipolar disorder ( 21926972) Cooked vegetable consumption ( 32066663) Dietary macronutrient intake ( 23372041) Elevated serum carcinoembryonic antigen levels ( 24941225) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Intake of total sugars ( 31005972) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Retinal vascular caliber ( 21060863) Serum alkaline phosphatase levels ( 33339817) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		33 interacting genes: BCAR1 BMI1 ECPAS EZR GGA3 GRSF1 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B MSN RAB7A RDX RILP RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45
Entrez ID		55823	2523
HPRD ID		12258	07186
Ensembl ID		ENSG00000160695	ENSG00000174951
Uniprot IDs		A0A087WXL6 B7Z879 Q9H270	P19526 Q6IZA2
PDB IDs
Enriched GO Terms of Interacting Partners?		Late Endosome Membrane Docking Vesicle Organization Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Endosome Vesicle-mediated Transport Intracellular Protein Transport Membrane Fusion Early Endosome Vacuolar Transport Endosome To Lysosome Transport Intracellular Protein Localization Lysosomal Transport Positive Regulation Of Catabolic Process Establishment Of Protein Localization Protein Transport Organelle Localization Macromolecule Catabolic Process Catabolic Process Vesicle Docking SNARE Binding Regulation Of Protein Localization Positive Regulation Of Protein Catabolic Process Cellular Localization Chloride Channel Inhibitor Activity CORVET Complex Clathrin-coated Vesicle Intracellular Transport Organelle Localization By Membrane Tethering Positive Regulation Of Early Endosome To Late Endosome Transport Autophagosome Membrane Organization Endosome Organization Late Endosome Membrane Positive Regulation Of Protein Localization To Early Endosome SNAP Receptor Activity Endosomal Transport Positive Regulation Of Protein Localization To Endosome Establishment Of Localization In Cell Endosome Membrane SNARE Complex HOPS Complex Autophagy Autophagosome Maturation Syntaxin Binding Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Metabolic Process	Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Vesicle Tethering Complex Positive Regulation Of Early Endosome To Late Endosome Transport CORVET Complex Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway HOPS Complex Regulation Of Early Endosome To Late Endosome Transport Syntaxin Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Vesicle Docking Involved In Exocytosis Autophagosome Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Clathrin-coated Vesicle Regulation Of Protein Targeting To Mitochondrion Endosome Organization Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Endosome To Lysosome Transport Endocytic Vesicle Regulation Of Intracellular Estrogen Receptor Signaling Pathway Vesicle Docking Positive Regulation Of Protein Targeting To Mitochondrion Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Lysosomal Transport Organelle Fusion Positive Regulation Of Intracellular Transport Late Endosome Membrane Late Endosome Membrane Fusion Vacuolar Transport Vacuole Organization Protein-macromolecule Adaptor Activity Positive Regulation Of Protein Catabolic Process Protein Domain Specific Binding Regulation Of Organelle Assembly Regulation Of Intracellular Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?