DCP1A and UPF1

Number of citations of the paper that reports this interaction (PMID 16364915)
154

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		DCP1A	UPF1
Gene Name		decapping mRNA 1A	UPF1 regulator of nonsense transcripts homolog (yeast)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Cytosol Membrane	Chromatin Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex
	Molecular Function	Protein Binding Hydrolase Activity Identical Protein Binding	DNA Binding Chromatin Binding RNA Binding ATP-dependent RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Gene Expression Histone MRNA Catabolic Process
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		14 interactors: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 PAXIP1 PNRC2 RITA1 SMAD4 TTF2 UPF1 XRN1 YWHAG	31 interactors: ABHD16A ACSS2 ATR CSNK2B DCP1A DCP2 DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG GSPT2 HIRA LSM8 NADSYN1 NDRG1 NDUFB10 PLEKHA5 PLEKHB2 POLR2A RHOXF2 RPRD2 SMG1 SMG5 STAU1 UPF2 UPF3A UPF3B XRN1
Entrez ID		55802	5976
HPRD ID		06113	03254
Ensembl ID		ENSG00000162290	ENSG00000005007
Uniprot IDs		B4DHN9 Q9NPI6 U3KQU1	Q92900
PDB IDs		2WX3 4B6H	2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Metabolic Process Gene Expression Histone MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Transcription, DNA-templated RNA Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleic Acid Phosphodiester Bond Hydrolysis MiRNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Peptidyl-lysine Acetylation Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Regulation Of Protein Metabolic Process Positive Regulation Of Protein Acetylation Epidermal Growth Factor Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Fibroblast Growth Factor Regulation Of RNA Biosynthetic Process Gene Silencing By MiRNA Regulation Of RNA Metabolic Process	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process RNA Localization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Surveillance MRNA Transport RNA Transport Gene Expression Catabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone MRNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Nuclear Export Nucleocytoplasmic Transport Nuclear Transport Nitrogen Compound Metabolic Process MRNA Export From Nucleus RNA Export From Nucleus Histone MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Metabolic Process Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression Regulation Of Translation RRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis Intracellular MRNA Localization RRNA Catabolic Process Positive Regulation Of Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Maturation Of 5.8S RRNA NcRNA Metabolic Process RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Formation Of Translation Preinitiation Complex RRNA Processing
Tagcloud ?		appears blockade bodies caf1 ccr4 cleavage coincident cytoplasmic decapping directed dispersion disrupts eif2alpha enter evh1 gfp infection infectious linking mammalian pan2 pan3 pkr poliovirus restricted restricts surprisingly translation translational	aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector
Tagcloud (Difference) ?		appears blockade bodies caf1 ccr4 cleavage coincident cytoplasmic decapping directed dispersion disrupts eif2alpha enter evh1 gfp infection infectious linking mammalian pan2 pan3 pkr poliovirus restricted restricts surprisingly translation translational	aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector
Tagcloud (Intersection) ?