DCP1A and RITA1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DCP1A	RITA1
Description		decapping mRNA 1A	RBPJ interacting and tubulin associated 1
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Dendrite Cytoplasmic Ribonucleoprotein Granule	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Identical Protein Binding 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	Protein Binding Tubulin Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping Protein Localization To Cytoplasmic Stress Granule	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Nervous System Development Neurogenesis Negative Regulation Of Notch Signaling Pathway Nuclear Export
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) PR interval ( 32439900) Refractive error ( 32231278) Spontaneous preterm birth (preterm delivery) ( 25599974)
Interacting Genes		16 interacting genes: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 MIR15B NSMAF PAXIP1 PNRC2 RAD52 RITA1 SMAD4 TTF2 UPF1 YWHAG	4 interacting genes: APP DCP1A GOLGA2 HOOK2
Entrez ID		55802	84934
HPRD ID		06113	08606
Ensembl ID		ENSG00000272886	ENSG00000139405
Uniprot IDs		Q9NPI6	Q96K30
PDB IDs		2WX3 4B6H	5EG6
Enriched GO Terms of Interacting Partners?		P-body Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Destabilization RISC Complex RNA Destabilization Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process MRNA Catabolic Process SiRNA-mediated Gene Silencing By MRNA Destabilization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation RISC-loading Complex Regulation Of Protein Metabolic Process Regulation Of MRNA Stability RNA Catabolic Process Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Gene Expression RISC Complex Assembly Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Nucleus Positive Regulation Of Gene Expression Cytoplasmic Ribonucleoprotein Granule Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Pre-miRNA Processing Histone MRNA Catabolic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Gene Expression Regulation Of Trophoblast Cell Migration MRNA Methylguanosine-cap Decapping Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Core Promoter Sequence-specific DNA Binding Regulation Of Telomere Maintenance	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Protein Homooligomerization Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Protein Complex Oligomerization Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Intracellular Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Lipoprotein Particle Growth Factor Receptor Binding Microtubule-based Process Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Vesicle-mediated Transport Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Identical Protein Binding Positive Regulation Of Protein Glycosylation Microtubule Binding Golgi Disassembly FHF Complex Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Axon Choice Point Recognition Regulation Of Protein Glycosylation Golgi Apparatus Heparan Sulfate Binding Signaling Receptor Activator Activity Protein Localization To Perinuclear Region Of Cytoplasm
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