DCP1A and TTF2

Number of citations of the paper that reports this interaction (PubMedID 12927788)
0

Data Source:
HPRD (two hybrid)

		DCP1A	TTF2
Description		decapping mRNA 1A	transcription termination factor 2
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Dendrite Cytoplasmic Ribonucleoprotein Granule	Nucleus Spliceosomal Complex Cytoplasm Cytosol Transcription Elongation Factor Complex
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Identical Protein Binding 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	Nucleotide Binding DNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping Protein Localization To Cytoplasmic Stress Granule	DNA Repair DNA-templated Transcription Termination Termination Of RNA Polymerase II Transcription MRNA Processing RNA Splicing
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) PR interval ( 32439900) Refractive error ( 32231278) Spontaneous preterm birth (preterm delivery) ( 25599974)
Interacting Genes		16 interacting genes: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 MIR15B NSMAF PAXIP1 PNRC2 RAD52 RITA1 SMAD4 TTF2 UPF1 YWHAG	27 interacting genes: CDC5L CDKL3 CEBPA CLPB DCP1A DRAP1 FZR1 GMEB2 HINFP HNRNPA1 HNRNPA2B1 KIF4A LINC01554 MATR3 MYB MYBL2 NVL PDCD6IP PRDX4 SKIL SMAD1 SMAD7 TACC3 TCF4 TNIP1 UBC ZSCAN1
Entrez ID		55802	8458
HPRD ID		06113	05280
Ensembl ID		ENSG00000272886	ENSG00000116830
Uniprot IDs		Q9NPI6	Q9UNY4
PDB IDs		2WX3 4B6H
Enriched GO Terms of Interacting Partners?		P-body Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Destabilization RISC Complex RNA Destabilization Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process MRNA Catabolic Process SiRNA-mediated Gene Silencing By MRNA Destabilization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation RISC-loading Complex Regulation Of Protein Metabolic Process Regulation Of MRNA Stability RNA Catabolic Process Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Gene Expression RISC Complex Assembly Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Nucleus Positive Regulation Of Gene Expression Cytoplasmic Ribonucleoprotein Granule Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Pre-miRNA Processing Histone MRNA Catabolic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Gene Expression Regulation Of Trophoblast Cell Migration MRNA Methylguanosine-cap Decapping Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Core Promoter Sequence-specific DNA Binding Regulation Of Telomere Maintenance	Nucleus Identical Protein Binding Nuclear Matrix DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process WD40-repeat Domain Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex MiRNA Binding Regulation Of Macromolecule Metabolic Process Heteromeric SMAD Protein Complex G-rich Strand Telomeric DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Primary MiRNA Processing Regulation Of Primary Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of RNA Metabolic Process Nucleoplasm Lens Fiber Cell Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process I-SMAD Binding Positive Regulation Of Cell Differentiation Catalytic Step 2 Spliceosome Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Protein Domain Specific Binding Mitotic Spindle Organization Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II DNA Damage Checkpoint Signaling DNA-templated Transcription Negative Regulation Of Cell Differentiation Regulation Of Chromosome Organization Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Leukemia Inhibitory Factor Blastocyst Formation Response To Leukemia Inhibitory Factor Positive Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Telomere Maintenance
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