DCP1A and AGO2

Number of citations of the paper that reports this interaction (PMID 15937477)
320

Data Source:
HPRD (in vivo)

		DCP1A	AGO2
Gene Name		decapping mRNA 1A	argonaute RISC catalytic component 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Cytosol Membrane	Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Membrane RISC Complex Ribonucleoprotein Complex Micro-ribonucleoprotein Complex
	Molecular Function	Protein Binding Hydrolase Activity Identical Protein Binding	RNA 7-methylguanosine Cap Binding MRNA Binding Translation Initiation Factor Activity Endoribonuclease Activity Protein Binding SiRNA Binding MiRNA Binding Poly(A) RNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Initiation Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Gene Expression MiRNA Metabolic Process Posttranscriptional Gene Silencing Gene Silencing By RNA Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Negative Regulation Of Translation Involved In Gene Silencing By MiRNA MRNA Cleavage Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Translational Initiation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Signaling by Wnt Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Transcriptional regulation by small RNAs Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 MicroRNA (miRNA) biogenesis Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Small interfering RNA (siRNA) biogenesis Adaptive Immune System
Drugs
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		14 interactors: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 PAXIP1 PNRC2 RITA1 SMAD4 TTF2 UPF1 XRN1 YWHAG	15 interactors: AGO1 BTRC DCP1A DCP2 DDX20 DHX58 DICER1 GEMIN4 MIRLET7B MIRLET7I PFKP PRKRA TARBP2 TBK1 TBKBP1
Entrez ID		55802	27161
HPRD ID		06113	06943
Ensembl ID		ENSG00000162290	ENSG00000123908
Uniprot IDs		B4DHN9 Q9NPI6 U3KQU1	A4FVC0 Q9UKV8
PDB IDs		2WX3 4B6H	3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4EI1 4EI3 4F3T
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Metabolic Process Gene Expression Histone MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Transcription, DNA-templated RNA Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleic Acid Phosphodiester Bond Hydrolysis MiRNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Peptidyl-lysine Acetylation Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Regulation Of Protein Metabolic Process Positive Regulation Of Protein Acetylation Epidermal Growth Factor Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Fibroblast Growth Factor Regulation Of RNA Biosynthetic Process Gene Silencing By MiRNA Regulation Of RNA Metabolic Process	Production Of SiRNA Involved In RNA Interference Posttranscriptional Gene Silencing RNA Interference Gene Silencing By RNA Gene Silencing Gene Silencing By MiRNA Cellular Response To DsRNA Targeting Of MRNA For Destruction Involved In RNA Interference Ribonucleoprotein Complex Assembly Negative Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression NcRNA Metabolic Process Regulation Of Gene Expression, Epigenetic Response To DsRNA MRNA Metabolic Process RNA Processing Pre-miRNA Processing Response To Virus Ribonucleoprotein Complex Biogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Organic Cyclic Compound Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Defense Response To Virus RNA Metabolic Process Aromatic Compound Catabolic Process MRNA Catabolic Process Defense Response To Virus Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process Gene Expression Catabolic Process Spliceosomal SnRNP Assembly Negative Regulation Of Type I Interferon Production Cellular Macromolecular Complex Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immune Response Response To Other Organism Defense Response Response To Biotic Stimulus Immune System Process Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Type I Interferon Production Regulation Of Defense Response To Virus Nucleobase-containing Compound Metabolic Process
Tagcloud ?		appears blockade bodies caf1 ccr4 cleavage coincident cytoplasmic decapping directed dispersion disrupts eif2alpha enter evh1 gfp infection infectious linking mammalian pan2 pan3 pkr poliovirus restricted restricts surprisingly translation translational	acf acriflavine aerosol alphaviruses avenue bioterror capsid degrading downregulating encephalitic encephalitis equine equines licensed loads master nile priority publications resultant risc stomatitis titers trd veev venezuelan vesicular virulent weapon
Tagcloud (Difference) ?		appears blockade bodies caf1 ccr4 cleavage coincident cytoplasmic decapping directed dispersion disrupts eif2alpha enter evh1 gfp infection infectious linking mammalian pan2 pan3 pkr poliovirus restricted restricts surprisingly translation translational	acf acriflavine aerosol alphaviruses avenue bioterror capsid degrading downregulating encephalitic encephalitis equine equines licensed loads master nile priority publications resultant risc stomatitis titers trd veev venezuelan vesicular virulent weapon
Tagcloud (Intersection) ?