DCP1A and DCP2

Number of citations of the paper that reports this interaction (PubMedID 12417715)
67

Data Source:
HPRD (two hybrid, in vitro)

		DCP1A	DCP2
Description		decapping mRNA 1A	decapping mRNA 2
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Dendrite Cytoplasmic Ribonucleoprotein Granule	P-body Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Identical Protein Binding 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	RNA Binding 5'-3' RNA Exonuclease Activity Protein Binding Hydrolase Activity RNA Exonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding Metal Ion Binding Telomerase RNA Binding 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping Protein Localization To Cytoplasmic Stress Granule	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Histone MRNA Catabolic Process Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) PR interval ( 32439900) Refractive error ( 32231278) Spontaneous preterm birth (preterm delivery) ( 25599974)	Waist circumference ( 32902719) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		16 interacting genes: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 MIR15B NSMAF PAXIP1 PNRC2 RAD52 RITA1 SMAD4 TTF2 UPF1 YWHAG	12 interacting genes: AGO1 AGO2 DCP1A DCP1B MIR15B MTOR NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2
Entrez ID		55802	167227
HPRD ID		06113	13125
Ensembl ID		ENSG00000272886	ENSG00000172795
Uniprot IDs		Q9NPI6	Q8IU60
PDB IDs		2WX3 4B6H	5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC
Enriched GO Terms of Interacting Partners?		P-body Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Destabilization RISC Complex RNA Destabilization Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process MRNA Catabolic Process SiRNA-mediated Gene Silencing By MRNA Destabilization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation RISC-loading Complex Regulation Of Protein Metabolic Process Regulation Of MRNA Stability RNA Catabolic Process Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Gene Expression RISC Complex Assembly Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Nucleus Positive Regulation Of Gene Expression Cytoplasmic Ribonucleoprotein Granule Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Pre-miRNA Processing Histone MRNA Catabolic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Gene Expression Regulation Of Trophoblast Cell Migration MRNA Methylguanosine-cap Decapping Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Core Promoter Sequence-specific DNA Binding Regulation Of Telomere Maintenance	P-body Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process RNA Catabolic Process Cytoplasmic Ribonucleoprotein Granule SiRNA-mediated Gene Silencing By MRNA Destabilization Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Gene Expression Positive Regulation Of Catabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation RISC-loading Complex Negative Regulation Of Protein Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Translation RISC Complex Assembly 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Cytosol Regulation Of Translation RNA Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Pre-miRNA Processing RISC Complex Autophagosome Assembly Regulation Of Trophoblast Cell Migration MRNA Methylguanosine-cap Decapping MRNA Destabilization Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Autophagosome Organization Negative Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Non-canonical NF-kappaB Signal Transduction RNA Decapping Exon-exon Junction Complex MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of MRNA Catabolic Process MiRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Metabolic Process Telomeric DNA Binding Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process RNA Polymerase II Complex Binding Positive Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process MiRNA Processing
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