DCP1A and DCP2

Number of citations of the paper that reports this interaction (PMID 12417715)
126

Data Source:
HPRD (two hybrid, in vitro)

		DCP1A	DCP2
Gene Name		decapping mRNA 1A	decapping mRNA 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Cytosol Membrane	Cytoplasmic MRNA Processing Body Nucleoplasm Cytosol RISC Complex Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Hydrolase Activity Identical Protein Binding	RNA Binding Protein Binding Exoribonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding M7G(5')pppN Diphosphatase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Catabolic Process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA ATF4 activates genes mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		14 interactors: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 PAXIP1 PNRC2 RITA1 SMAD4 TTF2 UPF1 XRN1 YWHAG	10 interactors: AGO1 AGO2 DCP1A DCP1B NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2
Entrez ID		55802	167227
HPRD ID		06113	13125
Ensembl ID		ENSG00000162290	ENSG00000172795
Uniprot IDs		B4DHN9 Q9NPI6 U3KQU1	Q8IU60
PDB IDs		2WX3 4B6H
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Metabolic Process Gene Expression Histone MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Transcription, DNA-templated RNA Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleic Acid Phosphodiester Bond Hydrolysis MiRNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Peptidyl-lysine Acetylation Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Regulation Of Protein Metabolic Process Positive Regulation Of Protein Acetylation Epidermal Growth Factor Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Fibroblast Growth Factor Regulation Of RNA Biosynthetic Process Gene Silencing By MiRNA Regulation Of RNA Metabolic Process	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Catabolic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA MiRNA Metabolic Process Posttranscriptional Regulation Of Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Regulation Of Gene Expression, Epigenetic Gene Silencing By MiRNA Gene Expression Cellular Nitrogen Compound Metabolic Process Posttranscriptional Gene Silencing Nucleocytoplasmic Transport Nuclear Transport Regulation Of Translation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Gene Silencing By RNA Negative Regulation Of Protein Metabolic Process MRNA Export From Nucleus RNA Export From Nucleus Negative Regulation Of Translation Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process RNA Metabolic Process Gene Silencing MRNA Cleavage Involved In Gene Silencing By MiRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA N-acetylmannosamine Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Nuclear Export MRNA Transport SiRNA Loading Onto RISC Involved In RNA Interference Negative Regulation Of Protein Deubiquitination Phosphatidylinositol-mediated Signaling RNA Transport Notch Signaling Pathway Positive Regulation Of Viral Entry Into Host Cell N-acetylneuraminate Catabolic Process RNA Localization
Tagcloud ?		appears blockade bodies caf1 ccr4 cleavage coincident cytoplasmic decapping directed dispersion disrupts eif2alpha enter evh1 gfp infection infectious linking mammalian pan2 pan3 pkr poliovirus restricted restricts surprisingly translation translational	accumulate actively bodies cleared constant decay depots ends engaged eukaryotes fate gradually intensively localizes machinery mammalian membranous mrnas ms2 regular relieved residing starvation stationary storage tagging tails translational visualization
Tagcloud (Difference) ?		appears blockade caf1 ccr4 cleavage coincident cytoplasmic decapping directed dispersion disrupts eif2alpha enter evh1 gfp infection infectious linking pan2 pan3 pkr poliovirus restricted restricts surprisingly translation	accumulate actively cleared constant decay depots ends engaged eukaryotes fate gradually intensively localizes machinery membranous mrnas ms2 regular relieved residing starvation stationary storage tagging tails visualization
Tagcloud (Intersection) ?		bodies mammalian translational