MINDY1 and GMCL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MINDY1	GMCL1
Description		MINDY lysine 48 deubiquitinase 1	germ cell-less 1, spermatogenesis associated
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nuclear Body Cell Periphery	Nucleus Nuclear Matrix
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Cysteine-type Carboxypeptidase Activity K48-linked Polyubiquitin Modification-dependent Protein Binding K48-linked Deubiquitinase Activity	Protein Binding Identical Protein Binding
	Biological Process	Proteolysis	Germ Cell Development Spermatogenesis Cell Differentiation
Pathways
Drugs
Diseases
GWAS			Atrial fibrillation ( 28416818 29892015 30061737) Colorectal or endometrial cancer ( 26621817) Red cell distribution width ( 32888494) Whole brain grey matter density ( 31530798)
Interacting Genes		6 interacting genes: CRYAA DAZAP2 ESR1 GMCL1 LSM8 UBC	98 interacting genes: APLF APOL6 AXIN1 BEGAIN BSCL2 BYSL CCDC13 CCDC25 CDC37 CFAP298 CFAP410 CHIC2 CIB3 CLK2 CUL3 EHHADH ELOA EMD EXOC3 FAM50B FKBP1B FLYWCH1 FOSL2 FOXR1 FRMD6 GAGE1 GAGE10 GAGE12B GAGE12G GAGE12I GAGE12J GAGE2A GAGE2C GAGE2E GAGE5 GLRX3 GOLGA2 GRAMD1A HYKK IL17F KANK2 KAT5 KIFC3 KLHL20 KPNA2 KRT75 LNX1 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR MYLIP MYO5B NEBL NFIL3 NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PIBF1 PIH1D2 PPP1R18 PTPN7 QRICH1 RAD54B RANBP3 RASA1 RNF4 RNMT SHQ1 SLC15A3 SNX20 SPATA31J1 STK3 SUMO1 SUMO1P1 SYT17 SYT6 TBC1D1 TLK2 TMPO TRIM13 TRIM21 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 YY1 ZBTB24 ZMYM2 ZNF23 ZNF250
Entrez ID		55793	64395
HPRD ID		07746	13587
Ensembl ID		ENSG00000143409	ENSG00000087338
Uniprot IDs		Q8N5J2	Q53SE7 Q96IK5
PDB IDs		5JKN 5JQS 5MN9 6TUV 6TXB 6Y6R 6YJG 6Z90
Enriched GO Terms of Interacting Partners?			Protein Binding Positive Regulation Of Viral Life Cycle Ubiquitin Protein Ligase Activity PML Body Protein Modification Process Regulation Of Viral Process Protein Localization To Cytoskeleton Protein Modification By Small Protein Conjugation Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Transcription Factor Binding Protein Sumoylation Cytoplasm Post-translational Protein Modification Small Protein Activating Enzyme Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Process Modification-dependent Protein Catabolic Process
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