AKAP7 and PRKAR1A

Number of citations of the paper that reports this interaction (PubMedID 12804576)
0

Data Source:
HPRD (two hybrid, in vivo)

		AKAP7	PRKAR1A
Description		A-kinase anchoring protein 7	protein kinase cAMP-dependent type I regulatory subunit alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Hippocampal Mossy Fiber To CA3 Synapse	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Plasma Membrane Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Synapse Ciliary Base Glutamatergic Synapse Sperm Head-tail Coupling Apparatus
	Molecular Function	Nucleotide Binding Protein Binding Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Action Potential Monoatomic Ion Transport Intracellular Protein Localization Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of Membrane Repolarization Cellular Response To CAMP Positive Regulation Of Potassium Ion Transmembrane Transport	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways			PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases			Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hip circumference adjusted for BMI ( 34021172) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		7 interacting genes: C8orf34 CEP76 PRKAR1A PRKAR2A ROPN1 ROPN1L SPA17	55 interacting genes: AKAP1 AKAP10 AKAP11 AKAP19 AKAP4 AKAP5 AKAP7 AKT1 ARFGEF2 BAHD1 BTG3 CAPN11 CBS CCNE1 CDK2 CDK4 CSTPP1 DSCR4 DSCR9 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAP1A MAP1B MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PSMG1 PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SNCA SPART TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		9465	5573
HPRD ID		16065	01786
Ensembl ID		ENSG00000118507	ENSG00000108946
Uniprot IDs		A0A804HI88 A0A9L9PYJ6 O43687 Q2TAJ5 Q6P4D3 Q9P0M2	B2R5T5 P10644
PDB IDs		4ZP3 5JJ2	5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Protein Kinase A Catalytic Subunit Binding CAMP Binding Sperm Capacitation Cilium Movement Negative Regulation Of CAMP/PKA Signal Transduction Motile Cilium Plasma Membrane Raft Regulation Of CAMP/PKA Signal Transduction Ciliary Base Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Microtubule-based Movement Axoneme Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Cilium Movement Involved In Cell Motility Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Centrosome Cell Maturation Protein-containing Complex Sperm Fibrous Sheath Developmental Maturation Microtubule-based Process Microtubule-based Transport Protein Domain Specific Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Developmental Process Involved In Reproduction Cellular Response To Glucagon Stimulus Radial Spoke Negative Regulation Of Activated T Cell Proliferation Ubiquitin Protein Ligase Binding Sperm Head-tail Coupling Apparatus Response To Glucagon	Protein Kinase A Regulatory Subunit Binding CAMP-dependent Protein Kinase Complex Protein Kinase A Binding Protein Phosphorylation Cytosol Phosphorylation Protein-containing Complex Ubiquitin Protein Ligase Binding Cytoplasm Peptidyl-serine Phosphorylation Regulation Of Protein Localization To Cell Periphery Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Biological Quality Signal Transduction Kinase Activity Protein Kinase Activity Cyclin E1-CDK2 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Regulation Of Lymphocyte Migration Intracellular Signaling Cassette Postsynapse Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Protein Localization Protein Domain Specific Binding Cell Surface Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Localization To Cell Periphery ERBB Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process CAMP-dependent Protein Kinase Activity Establishment Of Protein Localization TOR Signaling Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of T Cell Migration Odontoblast Differentiation Regulation Of Protein Kinase A Signaling Organelle Organization Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Membrane Enzyme Binding
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