AKAP7 and SPA17

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		AKAP7	SPA17
Description		A-kinase anchoring protein 7	sperm autoantigenic protein 17
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Hippocampal Mossy Fiber To CA3 Synapse	Extracellular Region Cytoplasm Cilium External Side Of Plasma Membrane Membrane Motile Cilium Sperm Fibrous Sheath Neuron Projection Sperm Principal Piece
	Molecular Function	Nucleotide Binding Protein Binding Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	Protein Binding Calmodulin Binding
	Biological Process	Action Potential Monoatomic Ion Transport Intracellular Protein Localization Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of Membrane Repolarization Cellular Response To CAMP Positive Regulation Of Potassium Ion Transmembrane Transport	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Spermatogenesis Single Fertilization Binding Of Sperm To Zona Pellucida
Pathways
Drugs
Diseases
GWAS		Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hip circumference adjusted for BMI ( 34021172) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Bipolar disorder ( 20351715)
Interacting Genes		7 interacting genes: C8orf34 CEP76 PRKAR1A PRKAR2A ROPN1 ROPN1L SPA17	5 interacting genes: ACTN2 AKAP3 AKAP7 MYL6B ROPN1
Entrez ID		9465	53340
HPRD ID		16065	12272
Ensembl ID		ENSG00000118507	ENSG00000064199
Uniprot IDs		A0A804HI88 A0A9L9PYJ6 O43687 Q2TAJ5 Q6P4D3 Q9P0M2	A0A172Q397 Q15506
PDB IDs		4ZP3 5JJ2	8J07
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Protein Kinase A Catalytic Subunit Binding CAMP Binding Sperm Capacitation Cilium Movement Negative Regulation Of CAMP/PKA Signal Transduction Motile Cilium Plasma Membrane Raft Regulation Of CAMP/PKA Signal Transduction Ciliary Base Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Microtubule-based Movement Axoneme Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Cilium Movement Involved In Cell Motility Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Centrosome Cell Maturation Protein-containing Complex Sperm Fibrous Sheath Developmental Maturation Microtubule-based Process Microtubule-based Transport Protein Domain Specific Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Developmental Process Involved In Reproduction Cellular Response To Glucagon Stimulus Radial Spoke Negative Regulation Of Activated T Cell Proliferation Ubiquitin Protein Ligase Binding Sperm Head-tail Coupling Apparatus Response To Glucagon	Positive Regulation Of Potassium Ion Transport Protein Kinase A Binding Structural Constituent Of Muscle Titin Z Domain Binding Intracellular Protein Localization Positive Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transport Actin Filament Uncapping Positive Regulation Of Monoatomic Ion Transmembrane Transport Sperm Motility Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Phospholipase C-activating Angiotensin-activated Signaling Pathway Microspike Assembly Positive Regulation Of Monoatomic Ion Transport Cilium Movement FATZ Binding Motile Cilium Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity LIM Domain Binding Sperm Fibrous Sheath Unconventional Myosin Complex Positive Regulation Of Endocytic Recycling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Postsynaptic Actin Cytoskeleton Positive Regulation Of Actin Filament Depolymerization Negative Regulation Of Protein Localization To Cell Surface Cell Projection Titin Binding Regulation Of Metal Ion Transport Actin Filament-based Process Postsynaptic Density, Intracellular Component Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Protein Depolymerization Regulation Of Monoatomic Ion Transport Pseudopodium Microtubule-based Movement Acrosome Reaction Sperm Capacitation Muscle Myosin Complex Actin-myosin Filament Sliding Muscle Filament Sliding Angiotensin-activated Signaling Pathway Regulation Of Endocytic Recycling Postsynaptic Cytoskeleton Organization Regulation Of Membrane Potential Positive Regulation Of Cation Channel Activity
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