HYAL1 and COL2A1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		HYAL1	COL2A1
Name		hyaluronidase 1	collagen type II alpha 1 chain
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle Hyaluranon Cable Lysosomal Lumen Extracellular Exosome	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Basement Membrane Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Virus Receptor Activity Hyalurononglucosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Chondroitin Hydrolase Activity	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Response To Reactive Oxygen Species Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Inflammatory Response Response To Virus Chondroitin Sulfate Proteoglycan Catabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Response To Antibiotic Cartilage Development Embryonic Skeletal Joint Morphogenesis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To PH Cellular Response To UV-B Positive Regulation Of Hyaluranon Cable Assembly	Skeletal System Development Cartilage Condensation Ossification Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Collagen Fibril Organization Notochord Development Limb Morphogenesis Inner Ear Morphogenesis Animal Organ Development Skeletal System Morphogenesis System Development Inner Ear Development Cartilage Development Roof Of Mouth Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Bone Development Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Anterior Head Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		CS/DS degradation Hyaluronan degradation MPS IX - Natowicz syndrome (Hyaluronan metabolism) MPS IX - Natowicz syndrome (CS/DS degradation)	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs		None	Collagenase clostridium histolyticum
Diseases		Mucopolysaccharidosis type IX (MPS9); Hyaluronidase deficiency	Osteoarthritis with mild chondrodysplasia Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
GWAS		Depressive symptom (appetite changes) (binary trait) ( 31530331 ) Depressive symptoms (binary sum-score) ( 31530331 ) Depressive symptoms (sum-score) ( 31530331 ) Sleep duration (short sleep) ( 30846698 )	Lymphocyte count ( 32888494 ) Macular thickness ( 30535121 ) Neutrophil percentage of white cells ( 32888494 ) Retinal detachment or retinal break ( 31816047 ) Rheumatoid arthritis ( 30891314 ) Triglyceride levels ( 32902719 )
Novel Interactors		1 novel interactors: PRKAR2A	None recorded
Interacting Genes		1 interacting genes: COL2A1	33 interacting genes: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B KEAP1 LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		3373	1280
HPRD ID		06146	00361
Ensembl ID		ENSG00000114378	ENSG00000139219
Uniprot IDs		A0A024R2X3 A0A0S2Z3Q0 B3KUI5 Q12794	P02458
PDB IDs		2PE4	1U5M 2FSE 2SEB 5NIR 5OCX 5OCY 6BIN 6HG7 6NIX 7NZE
GO Terms Enriched among Interactors		Fibrillar Collagen Trimer Collagen Type XI Trimer Otic Vesicle Development Collagen Type II Trimer Notochord Development Platelet-derived Growth Factor Binding MHC Class II Protein Binding Limb Bud Formation Anterior Head Development Nucleotide-activated Protein Kinase Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Embryonic Skeletal Joint Morphogenesis Proteoglycan Binding Protein Kinase A Catalytic Subunit Binding Cartilage Condensation Cartilage Development Involved In Endochondral Bone Morphogenesis CAMP Binding Cell Aggregation Head Development Negative Regulation Of CAMP/PKA Signal Transduction Endochondral Ossification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extracellular Matrix Structural Constituent Conferring Tensile Strength Cellular Response To BMP Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Plasma Membrane Raft Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ciliary Base Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Signal Transduction Heart Morphogenesis Inner Ear Development Collagen Fibril Organization Chondrocyte Differentiation Inner Ear Morphogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Bone Development Collagen Trimer Roof Of Mouth Development Embryonic Skeletal System Morphogenesis Proteoglycan Metabolic Process Basement Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Limb Morphogenesis Cartilage Development Skeletal System Morphogenesis Extracellular Matrix Structural Constituent	Extracellular Matrix Extracellular Region Collagen Binding Extracellular Matrix Structural Constituent Extracellular Space Animal Organ Development Cartilage Development Extracellular Matrix Binding Platelet Alpha Granule Lumen Developmental Process Cell Surface Extracellular Matrix Organization Extracellular Structure Organization Animal Organ Morphogenesis Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Response To Wounding Anatomical Structure Morphogenesis Bone Development Heparin Binding Positive Regulation Of Cell Migration Positive Regulation Of Glial Cell Differentiation Basement Membrane Positive Regulation Of Cell Motility Platelet-derived Growth Factor Binding Golgi Lumen Tube Morphogenesis Positive Regulation Of Locomotion Angiogenesis Regulation Of Cell Adhesion Extracellular Exosome Proteoglycan Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Skin Development Regulation Of Anatomical Structure Morphogenesis Cell Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Bone Mineralization Positive Regulation Of MiRNA Transcription Positive Regulation Of Fibroblast Proliferation Chondrocyte Differentiation Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Gliogenesis Positive Regulation Of Phosphorylation Collagen Metabolic Process Regulation Of Extracellular Matrix Organization Regulation Of Glial Cell Differentiation Connective Tissue Development