HYAL1 and COL2A1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HYAL1	COL2A1
Gene Name		hyaluronoglucosaminidase 1	collagen, type II, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Cytoplasmic Vesicle Hyaluranon Cable Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Virus Receptor Activity Hyalurononglucosaminidase Activity Transcription Factor Binding Hyaluronan Synthase Activity	Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Response To Reactive Oxygen Species Carbohydrate Metabolic Process Inflammatory Response Pathogenesis Response To Virus Positive Regulation Of Epithelial Cell Migration Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Catabolic Process Hyaluronan Metabolic Process Hyaluronan Biosynthetic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Cellular Response To Platelet-derived Growth Factor Stimulus Small Molecule Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Growth Response To Antibiotic Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Embryonic Skeletal Joint Morphogenesis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To PH Cellular Response To UV-B Positive Regulation Of Hyaluranon Cable Assembly	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Axon Guidance Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Inner Ear Morphogenesis Cartilage Development Palate Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism CS/DS degradation Hyaluronan uptake and degradation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Hyaluronan metabolism Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: COL2A1	33 interactors: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		3373	1280
HPRD ID		06146	00361
Ensembl ID		ENSG00000114378	ENSG00000139219
Uniprot IDs		B3KUI5 Q12794	P02458
PDB IDs		2PE4	1U5M 2FSE 2SEB
Enriched GO Terms of Interacting Partners?		Limb Bud Formation Otic Vesicle Development Embryonic Skeletal Joint Morphogenesis Embryonic Skeletal Joint Development Notochord Development Cartilage Condensation Cellular Response To BMP Stimulus Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Collagen Fibril Organization Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Chondrocyte Differentiation Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Inner Ear Morphogenesis Proteoglycan Metabolic Process Palate Development Bone Morphogenesis Ear Morphogenesis Embryonic Skeletal System Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Sensory Perception Of Sound Embryonic Skeletal System Development Visual Perception Sensory Perception Of Light Stimulus Tissue Homeostasis Limb Morphogenesis Sensory Perception Of Mechanical Stimulus Inner Ear Development Cartilage Development Regulation Of Extrinsic Apoptotic Signaling Pathway Limb Development Heart Morphogenesis Bone Development Ear Development Multicellular Organismal Homeostasis Connective Tissue Development Negative Regulation Of Apoptotic Signaling Pathway Skeletal System Morphogenesis Ossification Embryonic Organ Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Glycoprotein Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Connective Tissue Development Cartilage Development Skeletal System Development Anatomical Structure Morphogenesis Organ Morphogenesis System Development Multicellular Organismal Development Tissue Development Platelet Degranulation Anatomical Structure Development Positive Regulation Of Cell Migration Bone Development Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Growth Plate Cartilage Development Response To Wounding Extracellular Matrix Disassembly Organ Development Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Growth Factor Stimulus Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Hemostasis Response To Growth Factor Locomotion Collagen Catabolic Process Endochondral Bone Growth Regulation Of Epithelial Cell Migration Collagen Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Involved In Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Response To External Stimulus Regulation Of Cell Migration Organ Growth Platelet Activation Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Positive Regulation Of Endothelial Cell Migration Regulation Of Locomotion Bone Morphogenesis
Tagcloud ?		asn asparagine attenuated defect degrades demonstrated directed enzymatic enzyme functions glycosylated glycosylation ha hyaluronic hydrolytic mass moreover mutation n predicted regulated residues secretion significance site sites spectrometry three	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Difference) ?		asn asparagine attenuated defect degrades demonstrated directed enzymatic enzyme functions glycosylated glycosylation ha hyaluronic hydrolytic mass moreover mutation n predicted regulated residues secretion significance site sites spectrometry three	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Intersection) ?