ILK and FERMT2

Number of citations of the paper that reports this interaction (PubMedID 25086068)
64

Data Source:
BioGRID (biochemical, pull down, pull down, affinity chromatography technology)

		ILK	FERMT2
Description		integrin linked kinase	FERM domain containing kindlin 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Sarcomere Lamellipodium Cell Projection Anchoring Junction	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Cell Junction Lamellipodium Membrane I Band Cell Projection Anchoring Junction
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Actin Binding Integrin Binding Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Protein Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Protein Serine/threonine Kinase Activator Activity SMAD Binding Actin Filament Binding Protein Serine/threonine Kinase Binding
	Biological Process	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Mitotic Spindle Organization Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction Fibroblast Migration Schwann Cell Development Nerve Development Myelination In Peripheral Nervous System Cell Projection Organization Cell Differentiation Positive Regulation Of BMP Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation Platelet Aggregation Caveola Assembly Protein Localization To Cell Cortex Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Integrin Activation Positive Regulation Of Integrin Activation Adherens Junction Maintenance Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Vascular Permeability Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Focal Adhesion Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Limb Development Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Protein Localization To Cell Junction Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Cell-extracellular matrix interactions RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Malaria ( 31844061)	Alzheimer's disease (late onset) ( 24162737) Diastolic blood pressure ( 27841878) Glaucoma (primary angle closure) ( 27064256) Intraocular pressure ( 29617998 29785010 30054594 31959993) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 30046033 32439900) Prostate cancer ( 23535732) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28135244)
Interacting Genes		43 interacting genes: AKT1 CASP8 CASP9 CAV1 CEBPA CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 OGT PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746	9 interacting genes: APP CMTM5 CTNNB1 FBLIM1 ILK ITGB1 LIMS1 PARVA TRIM15
Entrez ID		3611	10979
HPRD ID		03842	06374
Ensembl ID		ENSG00000166333	ENSG00000073712
Uniprot IDs		Q13418 V9HWF0	Q96AC1
PDB IDs		2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB	2LGX 2LKO 2MSU 4F7H 6U4N 6XTJ
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell-substrate Adhesion Anchoring Junction Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell Migration Protein Kinase Binding Positive Regulation Of Cell Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Proteolysis Regulation Of Cellular Localization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Developmental Process Response To Growth Factor Positive Regulation Of Biosynthetic Process Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Gene Expression Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell-substrate Adhesion ERBB Signaling Pathway Regulation Of Locomotion Integrin Binding Heterotypic Cell-cell Adhesion Negative Regulation Of Developmental Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Actin Binding Regulation Of Actin Filament-based Process Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis T Cell Costimulation Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin	Anchoring Junction Focal Adhesion Cell Adhesion Cell-cell Adhesion Cell-substrate Adhesion Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Neural Precursor Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Cell-matrix Adhesion Developmental Cell Growth Regulation Of Developmental Process Positive Regulation Of Signal Transduction Developmental Growth Involved In Morphogenesis Regulation Of Neurotransmitter Uptake Integrin Binding Protein Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Neuroblast Proliferation Lamellipodium Cell Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Heterotypic Cell-cell Adhesion Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Canonical Wnt Signaling Pathway Intercalated Disc Regulation Of Neuroblast Proliferation Neuroblast Proliferation Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Junction Assembly Perinuclear Region Of Cytoplasm Cellular Response To Growth Factor Stimulus Positive Regulation Of Neural Precursor Cell Proliferation Amyloid-beta Complex Regulation Of Wnt Signaling Pathway Growth Cone Lamellipodium Synaptic Membrane Regulation Of Synapse Organization Visual Behavior Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Visual Learning
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