ILK and FERMT1

Number of citations of the paper that reports this interaction (PubMedID 25086068)
64

Data Source:
BioGRID (pull down)

		ILK	FERMT1
Description		integrin linked kinase	FERM domain containing kindlin 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Sarcomere Lamellipodium Cell Projection Anchoring Junction	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Cell Junction Ruffle Membrane Cell Projection Anchoring Junction Cell Periphery
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Integrin Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Mitotic Spindle Organization Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction Fibroblast Migration Schwann Cell Development Nerve Development Myelination In Peripheral Nervous System Cell Projection Organization Cell Differentiation Positive Regulation Of BMP Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation Platelet Aggregation Caveola Assembly Protein Localization To Cell Cortex Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation	Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Integrin Activation Positive Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Protein Import Into Nucleus Keratinocyte Proliferation Keratinocyte Migration Negative Regulation Of Timing Of Anagen Positive Regulation Of Transforming Growth Factor Beta Production Basement Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Stem Cell Proliferation
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases			Kindler syndrome
GWAS		Malaria ( 31844061)	Abdominal aortic aneurysm ( 27899403) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung function (low FEV1 vs high FEV1) ( 26423011) Retinal detachment or retinal break ( 31816047) Smooth-surface caries ( 24556642) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		43 interacting genes: AKT1 CASP8 CASP9 CAV1 CEBPA CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 OGT PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746	4 interacting genes: ILK ITGB1 PARVA SRPK1
Entrez ID		3611	55612
HPRD ID		03842	06388
Ensembl ID		ENSG00000166333	ENSG00000101311
Uniprot IDs		Q13418 V9HWF0	Q49AC8 Q54A15 Q9BQL6
PDB IDs		2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell-substrate Adhesion Anchoring Junction Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell Migration Protein Kinase Binding Positive Regulation Of Cell Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Proteolysis Regulation Of Cellular Localization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Developmental Process Response To Growth Factor Positive Regulation Of Biosynthetic Process Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Gene Expression Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell-substrate Adhesion ERBB Signaling Pathway Regulation Of Locomotion Integrin Binding Heterotypic Cell-cell Adhesion Negative Regulation Of Developmental Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Actin Binding Regulation Of Actin Filament-based Process Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis T Cell Costimulation Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin	Cell-substrate Adhesion Magnesium Ion Binding Heterotypic Cell-cell Adhesion Anchoring Junction Focal Adhesion Substrate Adhesion-dependent Cell Spreading Cell-cell Adhesion Regulation Of Neural Precursor Cell Proliferation Integrin Binding Cell-matrix Adhesion Neural Precursor Cell Proliferation Cellular Component Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Integrin-mediated Signaling Pathway Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Smooth Muscle Cell Chemotaxis Cell Adhesion Establishment Or Maintenance Of Cell Polarity Cell Migration Protein Localization To Cell Cortex Cytoskeleton Organization Cell Morphogenesis Lamellipodium Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Cell Motility Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Calcium-independent Cell-matrix Adhesion Regulation Of Collagen Catabolic Process Formation Of Radial Glial Scaffolds Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Cell Projection Organization C-X3-C Chemokine Binding Integrin Binding Involved In Cell-matrix Adhesion Myelin Sheath Abaxonal Region Collagen Binding Involved In Cell-matrix Adhesion Regulation Of Spontaneous Synaptic Transmission
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