ILK and ITGB1

Number of citations of the paper that reports this interaction (PubMedID 9736715)
33

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		ILK	ITGB1
Description		integrin linked kinase	integrin subunit beta 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Sarcomere Lamellipodium Cell Projection Anchoring Junction	Ruffle Cytoplasm Endosome Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Endosome Membrane Intercalated Disc Membrane Lamellipodium Filopodium Cytoplasmic Vesicle Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha4-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha6-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Integrin Alphav-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Cell Projection Dendritic Spine Receptor Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Anchoring Junction Synaptic Membrane Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Magnesium Ion Binding Virus Receptor Activity Fibronectin Binding Protease Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Coreceptor Activity Protein Kinase Binding C-X3-C Chemokine Binding Signaling Receptor Activity Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Collagen Binding Involved In Cell-matrix Adhesion Integrin Binding Involved In Cell-matrix Adhesion Protein Tyrosine Kinase Binding
	Biological Process	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Mitotic Spindle Organization Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction Fibroblast Migration Schwann Cell Development Nerve Development Myelination In Peripheral Nervous System Cell Projection Organization Cell Differentiation Positive Regulation Of BMP Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation Platelet Aggregation Caveola Assembly Protein Localization To Cell Cortex Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation	G1/S Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Angiogenesis In Utero Embryonic Development Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Phagocytosis Cellular Defense Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Neuroblast Proliferation Muscle Organ Development Myoblast Fusion Cell Population Proliferation Germ Cell Migration Visual Learning Regulation Of Collagen Catabolic Process Positive Regulation Of Fibroblast Migration Response To Muscle Activity Cell Migration Formation Of Radial Glial Scaffolds Central Nervous System Neuron Differentiation CD40 Signaling Pathway Cell Projection Organization Lamellipodium Assembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Neuron Projection Development Cell-substrate Adhesion Receptor Internalization Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Wound Healing, Spreading Of Epidermal Cells Maintenance Of Blood-brain Barrier Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of GTPase Activity Sarcomere Organization Myoblast Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Mesodermal Cell Differentiation Myoblast Fate Specification Axon Extension Dendrite Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Cardiac Cell Fate Specification Regulation Of Biological Quality Cellular Response To Low-density Lipoprotein Particle Stimulus Basement Membrane Organization Positive Regulation Of Wound Healing Cell-cell Adhesion Regulation Of Spontaneous Synaptic Transmission Reactive Gliosis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Synapse Pruning Negative Regulation Of Anoikis
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans Other semaphorin interactions Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CHL1 interactions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen MET activates PTK2 signaling MET interacts with TNS proteins RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle HCMV Early Events GPER1 signaling Potential therapeutics for SARS Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of the ureteric bud Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs			Antithymocyte immunoglobulin (rabbit) MK-0668 PLN-74809
Diseases
GWAS		Malaria ( 31844061)	Depression (quantitative trait) ( 20800221) Suicide in bipolar disorder ( 25917933)
Interacting Genes		43 interacting genes: AKT1 CASP8 CASP9 CAV1 CEBPA CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 OGT PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746	80 interacting genes: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD274 CD36 CD46 CD82 CD9 CD93 COL18A1 CRKL DAG1 DOK1 EGFR ENO1 EPS8 FBLN1 FBXO2 FERMT1 FERMT2 FERMT3 FHL2 FLNA FLNB FLT4 FN1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LAMTOR5 LGALS1 LGALS3BP LGALS8 MAP4K4 MET NCKIPSD NF2 NGF NME1 NMRK2 PDHB PIP5K1C PLAUR PRKCA PRKCE PTK2 PXN RAB25 RACK1 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 TSPAN7 UPF2 VCAM1 VCAN YWHAB
Entrez ID		3611	3688
HPRD ID		03842	00628
Ensembl ID		ENSG00000166333	ENSG00000150093
Uniprot IDs		Q13418 V9HWF0	P05556
PDB IDs		2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB	3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4 7CEB 7CEC 7NWL 7NXD 8RPQ 8W30 9B9J 9B9K 9CKV
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell-substrate Adhesion Anchoring Junction Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell Migration Protein Kinase Binding Positive Regulation Of Cell Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Proteolysis Regulation Of Cellular Localization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Developmental Process Response To Growth Factor Positive Regulation Of Biosynthetic Process Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Gene Expression Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell-substrate Adhesion ERBB Signaling Pathway Regulation Of Locomotion Integrin Binding Heterotypic Cell-cell Adhesion Negative Regulation Of Developmental Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Actin Binding Regulation Of Actin Filament-based Process Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis T Cell Costimulation Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin	Integrin Binding Focal Adhesion Cell Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Cell-substrate Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Integrin Complex Regulation Of Cell Motility Regulation Of Locomotion Cell Surface Regulation Of Cell-substrate Adhesion Plasma Membrane Cell Migration Positive Regulation Of Cell-substrate Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Cell Motility Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Anchoring Junction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Extracellular Exosome Signaling Receptor Activity Substrate Adhesion-dependent Cell Spreading Regulation Of Apoptotic Process Membrane Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Communication Cell-substrate Junction Assembly Anatomical Structure Morphogenesis Cell-substrate Junction Organization Integrin Activation Positive Regulation Of Signal Transduction Ruffle Membrane Regulation Of Cellular Component Organization Collagen Binding Involved In Cell-matrix Adhesion Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization
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