ILK and CAV1

Number of citations of the paper that reports this interaction (PMID 15722199)
6

Data Source:
HPRD (in vivo, in vitro)

		ILK	CAV1
Gene Name		integrin-linked kinase	caveolin 1, caveolae protein, 22kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Sarcomere Lamellipodium Cell Junction Neuronal Cell Body Costamere Terminal Bouton Dendritic Shaft Protein Complex	Golgi Membrane Acrosomal Membrane Intracellular Endosome Endoplasmic Reticulum Lipid Particle Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Signal Transducer Activity Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding	Receptor Binding Patched Binding Structural Molecule Activity Protein Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Complex Scaffold Identical Protein Binding Ion Channel Binding Nitric-oxide Synthase Binding Inward Rectifier Potassium Channel Inhibitor Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Aging Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Negative Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Nerve Development Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Myelin Assembly Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Extracellular Fibril Organization Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis Protein Heterooligomerization Positive Regulation Of Protein Kinase B Signaling Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Neural Precursor Cell Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Inactivation Of MAPK Activity Angiogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Calcium Ion Transport Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Blood Coagulation Protein Localization Cellular Response To Starvation Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Peptidase Activity Viral Process Vesicle Organization Regulation Of Fatty Acid Metabolic Process Lipid Storage Regulation Of Blood Coagulation Cholesterol Transport Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Maintenance Of Protein Location In Cell Response To Progesterone Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Homeostasis Vasoconstriction Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Response To Estrogen Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Nitric Oxide Metabolic Process Negative Regulation Of JAK-STAT Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Metalloenzyme Activity Leukocyte Migration Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Response To Calcium Ion Membrane Depolarization Regulation Of Peptidase Activity Calcium Ion Homeostasis Mammary Gland Involution Negative Regulation Of Protein Tyrosine Kinase Activity Caveola Assembly Cellular Response To Hyperoxia Caveolin-mediated Endocytosis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Inward Rectifier Potassium Channel Activity Protein Localization To Basolateral Plasma Membrane Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Cell junction organization Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Metabolism of lipids and lipoproteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Lipid digestion, mobilization, and transport Signaling by Wnt Basigin interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall eNOS activation disassembly of the destruction complex and recruitment of AXIN to the membrane Metabolism of nitric oxide Signaling by VEGF TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis NOSTRIN mediated eNOS trafficking VEGFR2 mediated vascular permeability XAV939 inhibits tankyrase, stabilizing AXIN eNOS activation and regulation Signaling by WNT in cancer
Drugs
Diseases
GWAS			Atrial fibrillation ( 22544366) Electrocardiographic traits ( 20062063) Glaucoma (primary open-angle) ( 20835238) PR interval ( 20062060 23139255)
Protein-Protein Interactions		35 interactors: AKT1 CASP8 CASP9 CAV1 CKB GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746	81 interactors: ABCB1 ABL1 ADRBK1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FYN GJA1 GJA3 GJB2 GNAI2 GRB7 GRK1 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KDR LATS1 LRP1 MALL MAPK1 MAPK3 MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TGFBR1 TNFRSF1B TRAF2 TRAF6 TRPC1 VCP
Entrez ID		3611	857
HPRD ID		03842	03028
Ensembl ID		ENSG00000166333	ENSG00000105974
Uniprot IDs		B7Z1I0 B7Z418 Q13418	A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3
PDB IDs		2KBX 3F6Q 3IXE 3KMU 3KMW 3REP
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Junction Assembly Cell-substrate Adhesion Response To Growth Factor Positive Regulation Of Signal Transduction Cell-matrix Adhesion Cytoskeleton Organization Regulation Of Cellular Amino Acid Metabolic Process Cell Adhesion Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Immune System Process Actin Filament-based Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Ketone Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Heterotypic Cell-cell Adhesion Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Reorganization Single Organismal Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Wound Healing Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Epithelial Cell Proliferation Cell Migration Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell Morphogenesis Angiogenesis Response To Fibroblast Growth Factor Cell Motility Enzyme Linked Receptor Protein Signaling Pathway	Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Signal Transduction Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Response To External Stimulus Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Wound Healing Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Wounding Positive Regulation Of Phosphorylation Cell Development Regulation Of Catalytic Activity Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Kinase Activity Regulation Of Body Fluid Levels Chemotaxis Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Catalytic Activity Blood Coagulation Anatomical Structure Development Hemostasis Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Tissue Development Intracellular Signal Transduction Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway System Development Neurotrophin Signaling Pathway Neuron Projection Morphogenesis Response To Stress Cell Morphogenesis Involved In Neuron Differentiation
Tagcloud ?		bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous	17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Difference) ?		bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous	17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
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