LIMS2 and KRT40

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LIMS2	KRT40
Gene Name		LIM and senescent cell antigen-like domains 2	keratin 40, type I
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Focal Adhesion	Intermediate Filament
	Molecular Function	Zinc Ion Binding	Structural Molecule Activity
	Biological Process	Single Organismal Cell-cell Adhesion Cell Junction Assembly Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Hepatocyte Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Cell junction organization Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		13 interactors: APP CALCOCO2 GOLGA2 HIPK3 ILK KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 MDFI MTUS2 NOTCH2NL RCHY1	313 interactors: ADAMTSL3 AEN AES AKAP17A ALDH3B1 ALS2CR11 ANKRD36BP1 AP1M1 AQP1 AQP5 ARID5A ARMC7 ARSI ASMTL ATPAF2 AVPI1 BAHD1 BARD1 BCAS2 BEX2 BMS1P5 BYSL C10orf62 C11orf87 C14orf105 C19orf57 C19orf66 C19orf73 C1orf109 C1orf216 C20orf195 C22orf46 C5orf60 C6orf165 C6orf226 C8orf48 CA6 CARD9 CATIP CBX8 CCDC112 CCDC120 CCDC146 CCDC185 CCDC26 CCDC93 CCER1 CCHCR1 CCNG1 CD33 CDC20B CDK18 CDK5R1 CELA2B CEP57 CEP57L1 CHCHD2 CHCHD3 CHIC2 CLEC18A CNTF COL8A1 COMT COX5A CREB5 CTSZ CWF19L2 CYCS CYTH4 DAAM2 DCDC2B DCX DDX6 DLGAP2 DMRT3 DOCK2 DOCK8 DTNB EIF4E2 EXOC3-AS1 FAM107A FAM124B FAM214A FAM27E3 FAM64A FAM71C FAM74A4 FAM90A1 FARS2 FASLG FBF1 FBXL18 FBXO34 FBXW5 FKBP1B FOXB1 FRG1 GATA2 GATAD2A GEM GFOD1 GGN GLIDR GNAI2 GNG5 GOLGA6L2 GPATCH2L GTF3C5 GUCD1 HAUS1 HBA2 HBZ HCK HDAC4 HGS HOXA1 HSPA12B HSPD1 ING5 INPP5D IQUB ISCU ITGB5 JOSD1 KAT5 KCTD9 KIFC3 KLHL38 KPNA2 KRT2 KRT20 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT8 KRT81 LAGE3 LCE3E LENG1 LIMS2 LIN37 LINC00636 LINC01588 LMF2 LMO1 LMO2 LMO4 LOC149950 LRCH4 MAB21L2 MAGOHB MAPKBP1 MARK4 MED8 METTL17 MFAP1 MOB3C MOS MRPL11 MTA1 MXI1 NAB2 NAPRT NDEL1 NEK6 NFKBID NINJ1 NPBWR2 NPPB NR1D2 NXF1 OPCML OTUB2 PDLIM5 PGLS PHF21A PIGS PIN1 PKD2 POLDIP3 POLL POM121L8P POP5 PPP1R18 PRAM1 PRKAA1 PRKAB2 PRPF31 PSMA1 PSMC5 PTGER3 PTPMT1 PXMP2 QPRT RAB3IL1 RAB3IP RAC1 RASSF5 RBM41 RCOR3 RECK RNF213 RPL11 RSPH14 RTP5 RWDD2B SCOC SEMA4C SETD5 SH2D4A SHC3 SIRPA SLC25A10 SLIRP SLU7 SMARCE1 SMCO4 SNAI1 SNHG11 SNRPB SNW1 SPATA24 SPEF1 SPG7 SRSF2 SSX2 SSX2IP SYT6 TAPBPL TBC1D16 TBC1D22B TCEA2 TCEB3 TCHP THAP7 TIE1 TMEM231 TMEM241 TMSB4X TNIP3 TNNT1 TRAF4 TRIM42 TROAP TRPV6 TSC22D4 TSGA10IP TSHZ3 TTC23 TTC25 TTLL10 TXLNA TXN2 TXNDC5 TYK2 TYRO3 UACA UBASH3A UCMA USHBP1 USP2 USP21 UTP14C UTP23 UXT WDR25 WT1 WT1-AS ZBTB16 ZBTB24 ZBTB38 ZC2HC1C ZFHX3 ZFP2 ZFP69B ZFYVE21 ZFYVE26 ZGPAT ZMAT2 ZNF101 ZNF124 ZNF138 ZNF165 ZNF20 ZNF202 ZNF230 ZNF250 ZNF26 ZNF266 ZNF286A ZNF317 ZNF329 ZNF337 ZNF417 ZNF439 ZNF446 ZNF488 ZNF490 ZNF564 ZNF569 ZNF581 ZNF587 ZNF625 ZNF655 ZNF697 ZNF702P ZNF792 ZNF844 ZNRF2P1 ZSCAN21
Entrez ID		55679	125115
HPRD ID		06389	08304
Ensembl ID		ENSG00000072163	ENSG00000204889
Uniprot IDs		B3KNZ3 Q7Z4I7	Q6A162
PDB IDs		3IXE
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Binding Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of JUN Kinase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Binding Regulation Of Phosphorylation Synaptic Growth At Neuromuscular Junction Peptidyl-serine Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Notch Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Binding Regulation Of JNK Cascade Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Catalytic Activity Platelet Activation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Protein Metabolic Process Phosphorylation Positive Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity Axon Choice Point Recognition Negative Regulation Of Protein Metabolic Process Negative Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Neuron Remodeling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of JUN Kinase Activity Regulation Of Developmental Growth Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Fibroblast Migration Extracellular Fibril Organization Negative Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity MRNA Transcription Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Migration	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Defense Response To Virus By Virus Regulation Of Cell Death Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Apoptotic Process Bicarbonate Transport Cell Death Death Centrosome Organization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Cytoskeleton Organization Microtubule Organizing Center Organization Positive Regulation Of Cellular Protein Metabolic Process Intermediate Filament-based Process Organelle Organization Multicellular Organismal Development
Tagcloud ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 herc6 ifi16 ifnt insemination loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Difference) ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 herc6 ifi16 ifnt insemination loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
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