LIMS2 and MDFI

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LIMS2	MDFI
Gene Name		LIM and senescent cell antigen-like domains 2	MyoD family inhibitor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Focal Adhesion	Nucleus Cytoplasm
	Molecular Function	Zinc Ion Binding	Protein Binding Transcription Factor Binding
	Biological Process	Single Organismal Cell-cell Adhesion Cell Junction Assembly Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Hepatocyte Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of JUN Kinase Activity Embryo Development Dorsal/ventral Axis Specification Negative Regulation Of Wnt Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA Binding Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation
Pathways		Cell junction organization Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		13 interactors: APP CALCOCO2 GOLGA2 HIPK3 ILK KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 MDFI MTUS2 NOTCH2NL RCHY1	225 interactors: AANAT AASDHPPT ADAMTSL3 AKAP17A AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ATG12 ATN1 ATXN7L2 AVPI1 B3GNT9 BAALC BAHD1 BBS2 BEX1 C10orf62 C14orf105 C17orf70 C19orf60 C19orf66 C20orf195 C22orf39 C4orf26 C5orf30 C6orf165 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBX2 CC2D1B CCDC116 CCDC120 CCDC185 CCDC33 CCER1 CDC42EP1 CDCA7L CDKL3 CEP57L1 CHIC2 CLPB CNNM3 CPSF3L CREB5 CRX CRY1 CSNK1G2-AS1 CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNPEP DOCK2 DUSP6 EBI3 EIF4A2 EIF4E2 ENKD1 ETNK2 EWSR1 FAM124B FAM161A FAM27E3 FASTK FBXL18 FBXO34 FBXW5 FES FOXD4L6 FZD9 GATA2 GDF15 GLIDR GNAI2 GNG5 GPATCH2L GPRIN2 GTF3C5 HEYL HNRNPLL HOXA1 HOXB9 HTR1B ILF3 IQUB KAT5 KIAA0040 KIAA0408 KIF1A KPNA2 KRAS LASP1 LCE1B LCE3E LCE4A LIMS2 LINC00636 LINC01588 LMO3 LOC148413 LOC149950 LRCH4 LRRN4 MAGED1 MAGEF1 MAPKBP1 MCM5 METTL17 MFSD3 MGAT5B MVP MYF5 MYOD1 MYOG NAB2 NDUFA7 NEU4 NPDC1 NR1H2 NR1H3 OLIG3 OTX1 PARP11 PBXIP1 PDGFB PDIA5 PGLS PHLDA1 PID1 PIDD1 PIH1D2 PIN1 PLEKHG4 POM121L8P PRKAB2 PTPMT1 PVRL2 RABL6 REG3A RFX2 RIPPLY1 RTP5 SERF2 SFI1 SIX1 SLC25A10 SLC35A2 SLC9A1 SPATA3 SPATA8 SPG7 SPRY1 SPRY2 TAP1 TCEB3 TCF3 TGIF1 THAP7 THEG TIE1 TINAGL1 TMEM241 TNNI1 TNP2 TRAF3IP2 TRPC1 TRPV6 TSC2 TTC23 TTLL10 TUSC2 TYMSOS TYRO3 UBC USP20 USP6 VHL VPS72 WDYHV1 WNT11 ZBTB24 ZBTB25 ZBTB9 ZFYVE26 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF223 ZNF230 ZNF264 ZNF266 ZNF408 ZNF417 ZNF426 ZNF433 ZNF439 ZNF440 ZNF490 ZNF559 ZNF564 ZNF578 ZNF581 ZNF587 ZNF607 ZNF646 ZNF670 ZNF679 ZNF707 ZNF764 ZNF79 ZNF844
Entrez ID		55679	4188
HPRD ID		06389	07280
Ensembl ID		ENSG00000072163	ENSG00000112559
Uniprot IDs		B3KNZ3 Q7Z4I7	B1AKB6 Q99750
PDB IDs		3IXE
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Binding Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of JUN Kinase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Binding Regulation Of Phosphorylation Synaptic Growth At Neuromuscular Junction Peptidyl-serine Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Notch Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Binding Regulation Of JNK Cascade Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Catalytic Activity Platelet Activation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Protein Metabolic Process Phosphorylation Positive Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity Axon Choice Point Recognition Negative Regulation Of Protein Metabolic Process Negative Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Neuron Remodeling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of JUN Kinase Activity Regulation Of Developmental Growth Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Fibroblast Migration Extracellular Fibril Organization Negative Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity MRNA Transcription Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Migration	Transcription, DNA-templated RNA Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Developmental Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Myoblast Fusion Cell Fate Commitment Positive Regulation Of Skeletal Muscle Fiber Development Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Transcription From RNA Polymerase II Promoter Organ Development Metabolic Process
Tagcloud ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 herc6 ifi16 ifnt insemination loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Difference) ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 herc6 ifi16 ifnt insemination loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
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