MFN1 and PARK2

Number of citations of the paper that reports this interaction (PMID 23503661)
42

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study)

		MFN1	PARK2
Gene Name		mitofusin 1	parkin RBR E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane Integral Component Of Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Aggresome SCF Ubiquitin Ligase Complex Neuron Projection Perinuclear Region Of Cytoplasm LUBAC Complex Lewy Body Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding	G-protein Coupled Receptor Binding Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Tubulin Binding Ligase Activity SH3 Domain Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding
	Biological Process	Mitochondrial Fusion	Protein Polyubiquitination Mitochondrial Fission Mitochondrion Degradation Negative Regulation Of Protein Phosphorylation Startle Response Transcription, DNA-templated Protein Monoubiquitination Response To Oxidative Stress Mitochondrion Organization Central Nervous System Development Learning Adult Locomotory Behavior Regulation Of Autophagy Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Regulation Of Dopamine Secretion Protein Ubiquitination Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination Norepinephrine Metabolic Process Dopamine Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Cellular Protein Catabolic Process Protein K27-linked Ubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Protein Stabilization Dopamine Uptake Involved In Synaptic Transmission Protein Autoubiquitination Zinc Ion Homeostasis Negative Regulation Of Cell Death Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Cellular Response To Manganese Ion Protein K6-linked Ubiquitination Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Neuron Death Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Regulation Of Mitochondrion Degradation Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Factors involved in megakaryocyte development and platelet production	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Aging ( 22773346) Disc degeneration (lumbar) ( 22993228) Metabolite levels ( 19043545) Pancreatic cancer ( 20686608)
Protein-Protein Interactions		2 interactors: BAK1 PARK2	77 interactors: AIMP2 ARR3 ARRB2 ATXN3 BAG5 CASK CASP1 CASP8 CDK5 CHPF CRX CSNK1A1 CUL1 DLG1 DLX2 DNM1L DYT10 EPS15 FAM46C FBP1 FBXO7 FBXW7 GPR37 GRIN2B HEXDC IKBKG MEOX1 MEOX2 MFN1 NDUFA4L2 PAFAH1B2 PDCD2 PICK1 PRKACA PSMA1 PSMA7 PSMC5 PSMD4 RAC1 RAD1 RAD23A RANBP2 RBCK1 REL RGS2 RGS3 SEPT4 SEPT5 SIM2 SNCA SNCAIP STUB1 SYT11 TCF4 TOMM40 TOMM70A TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2J1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2V1 UCHL1 YWHAH ZNF746
Entrez ID		55669	5071
HPRD ID		16344	03967
Ensembl ID		ENSG00000171109	ENSG00000185345
Uniprot IDs		Q8IWA4	O60260 Q5VVX4
PDB IDs			1IYF 2JMO 4BM9 4I1F 4I1H
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Response To Endoplasmic Reticulum Stress Response To Toxic Substance Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Regulation Of Binding Positive Regulation Of Protein Linear Polyubiquitination Fibroblast Apoptotic Process Positive Regulation Of Proteolysis Negative Regulation Of Protein Phosphorylation Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine B Cell Negative Selection Mitochondrion Organization Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Response To Mycotoxin Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Post-embryonic Camera-type Eye Morphogenesis Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Metal Ion Homeostasis Response To Inorganic Substance Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Ion Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Apoptotic Process Involved In Patterning Of Blood Vessels Thymocyte Apoptotic Process B Cell Apoptotic Process Post-embryonic Organ Morphogenesis Positive Regulation Of Cell Death Regulation Of Ion Transport Positive Regulation Of Mitochondrial Fission Regulation Of Proteolysis	Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Death Death Positive Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Protein Ubiquitination Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Positive Regulation Of Signal Transduction Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Tagcloud ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fis1 fission injected mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle	ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Difference) ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fis1 fission injected mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle	ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Intersection) ?