MFN1 and BAK1

Number of citations of the paper that reports this interaction (PMID 19168699)
19

Data Source:
HPRD (in vivo)

		MFN1	BAK1
Gene Name		mitofusin 1	BCL2-antagonist/killer 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Integral Component Of Mitochondrial Outer Membrane Pore Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Chaperone Binding BH Domain Binding
	Biological Process	Mitochondrial Fusion	B Cell Homeostasis B Cell Apoptotic Process Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection Apoptotic Process Brain Development Aging Mitochondrial Fusion Cell Proliferation Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Fungus Response To Mycotoxin Response To UV-C Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Endocrine Pancreas Development Organ Regeneration Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To UV Limb Morphogenesis Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Fibroblast Apoptotic Process Response To Ethanol Positive Regulation Of Proteolysis Regulation Of Mitochondrial Membrane Permeability Post-embryonic Camera-type Eye Morphogenesis Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels
Pathways		Factors involved in megakaryocyte development and platelet production	Programmed Cell Death Activation and oligomerization of BAK protein Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 22700719) Hematological parameters ( 19820697) Mean platelet volume ( 22423221) Obesity-related traits ( 23251661) Platelet counts ( 22139419 23263863 20139978) Testicular germ cell tumor ( 19483681 23666239 23666240)
Protein-Protein Interactions		2 interactors: BAK1 PARK2	19 interactors: ARHGDIA BAX BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BID DBN1 ERN1 HERC1 HSD17B4 HSPD1 MCL1 MFN1 NFKBIB TP53 VDAC1 VDAC2
Entrez ID		55669	578
HPRD ID		16344	02744
Ensembl ID		ENSG00000171109	ENSG00000030110
Uniprot IDs		Q8IWA4	Q16611
PDB IDs			1BXL 2IMS 2IMT 2JBY 2JCN 2M5B 2XPX 2YV6 3I1H 3QBR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Response To Endoplasmic Reticulum Stress Response To Toxic Substance Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Regulation Of Binding Positive Regulation Of Protein Linear Polyubiquitination Fibroblast Apoptotic Process Positive Regulation Of Proteolysis Negative Regulation Of Protein Phosphorylation Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine B Cell Negative Selection Mitochondrion Organization Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Response To Mycotoxin Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Post-embryonic Camera-type Eye Morphogenesis Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Metal Ion Homeostasis Response To Inorganic Substance Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Ion Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Apoptotic Process Involved In Patterning Of Blood Vessels Thymocyte Apoptotic Process B Cell Apoptotic Process Post-embryonic Organ Morphogenesis Positive Regulation Of Cell Death Regulation Of Ion Transport Positive Regulation Of Mitochondrial Fission Regulation Of Proteolysis	Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Apoptotic Process Regulation Of Cell Death Neuron Apoptotic Process Mitochondrial Membrane Organization Neuron Death Cellular Response To DNA Damage Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Cell Death Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cell Proliferation Regulation Of Signaling Negative Regulation Of Signal Transduction Response To Gamma Radiation Cellular Response To Stress Male Gonad Development Negative Regulation Of Signaling Mitochondrial Transport Positive Regulation Of Mitochondrion Organization Response To Stress
Tagcloud ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fis1 fission injected mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fis1 fission injected mfn2 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?