NPLOC4 and UFD1

Number of citations of the paper that reports this interaction (PubMedID 11574150)
0

Data Source:
HPRD (two hybrid)

		NPLOC4	UFD1
Description		NPL4 homolog, ubiquitin recognition factor	ubiquitin recognition factor in ER associated degradation 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network	Nucleus Nucleoplasm Cytoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding ATPase Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production ERAD Pathway Negative Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production ERAD Pathway Negative Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein
Pathways		Translesion Synthesis by POLH Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Translesion Synthesis by POLH Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Central corneal thickness ( 32528159) Eye color traits ( 20463881) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myopia ( 27182965) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 28957414 32888494 27863252) Refractive astigmatism ( 30306274) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: CDC42 ERCC6 GZMK MAP3K1 RAF1 TMUB1 UBC UFD1 VPS26B	23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TMUB1 TP53 UBC VCP
Entrez ID		55666	7353
HPRD ID		06975	06778
Ensembl ID		ENSG00000182446	ENSG00000070010
Uniprot IDs		Q8TAT6	Q541A5 Q92890
PDB IDs		7WWP 7WWQ	2YUJ 5B6C 5C1B 7WWQ
Enriched GO Terms of Interacting Partners?		Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Protein Metabolic Process MAP Kinase Kinase Kinase Activity MAPK Cascade Intracellular Protein Localization Intracellular Signaling Cassette GBD Domain Binding Storage Vacuole Phagocytic Vesicle Cellular Response To Type II Interferon Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Death-inducing Signaling Complex Assembly ERAD Pathway UFD1-NPL4 Complex Response To Type II Interferon	Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Intracellular Signaling Cassette BAT3 Complex Binding ERAD Pathway Intracellular Protein Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Macroautophagy Protein Metabolic Process Growth Cone Proteasomal Protein Catabolic Process Cytosol Macromolecule Catabolic Process Derlin-1 Retrotranslocation Complex Protein Transport VCP-NPL4-UFD1 AAA ATPase Complex Ubiquitin-dependent Protein Catabolic Process K48-linked Polyubiquitin Modification-dependent Protein Binding Catabolic Process Intracellular Transport Activation Of Membrane Attack Complex Protein Catabolic Process Negative Regulation Of Complement Activation Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Regulation Of Immune Response Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Opsonization Retrograde Protein Transport, ER To Cytosol Macromolecule Metabolic Process Intracellular Protein Localization Ubiquitin-specific Protease Binding Symbiont Cell Surface Intracellular Signal Transduction Regulation Of Fibroblast Apoptotic Process Ubiquitin Binding Negative Regulation Of Autophagy Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Small GTPase-mediated Signal Transduction Regulation Of Complement Activation MAP Kinase Kinase Kinase Activity Extracellular Space Regulation Of Mitochondrion Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Localization Blood Microparticle
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