NPLOC4 and VPS26B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NPLOC4	VPS26B
Description		NPL4 homolog, ubiquitin recognition factor	VPS26 retromer complex component B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Membrane Retromer Complex Retromer, Cargo-selective Complex Phagocytic Vesicle Postsynaptic Recycling Endosome Postsynaptic Early Endosome Glutamatergic Synapse
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding ATPase Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production ERAD Pathway Negative Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Intracellular Protein Transport Protein Transport Regulation Of Macroautophagy Retrograde Transport, Endosome To Golgi Cellular Response To Type II Interferon Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways		Translesion Synthesis by POLH Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Central corneal thickness ( 32528159) Eye color traits ( 20463881) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myopia ( 27182965) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 28957414 32888494 27863252) Refractive astigmatism ( 30306274) Refractive error ( 32231278)	Age at first sexual intercourse ( 34211149) Verbal declarative memory ( 25648963)
Interacting Genes		9 interacting genes: CDC42 ERCC6 GZMK MAP3K1 RAF1 TMUB1 UBC UFD1 VPS26B	2 interacting genes: NPLOC4 VPS35
Entrez ID		55666	112936
HPRD ID		06975	14395
Ensembl ID		ENSG00000182446	ENSG00000151502
Uniprot IDs		Q8TAT6	Q4G0F5
PDB IDs		7WWP 7WWQ
Enriched GO Terms of Interacting Partners?		Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Protein Metabolic Process MAP Kinase Kinase Kinase Activity MAPK Cascade Intracellular Protein Localization Intracellular Signaling Cassette GBD Domain Binding Storage Vacuole Phagocytic Vesicle Cellular Response To Type II Interferon Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Death-inducing Signaling Complex Assembly ERAD Pathway UFD1-NPL4 Complex Response To Type II Interferon	Poly(C) RNA Binding Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network UFD1-NPL4 Complex Positive Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Protein Homooligomerization Mitochondrion-derived Vesicle Positive Regulation Of Wnt Protein Secretion Negative Regulation Of Late Endosome To Lysosome Transport Retromer, Cargo-selective Complex Positive Regulation Of Dopamine Biosynthetic Process Regulation Of Terminal Button Organization Regulation Of Dopamine Biosynthetic Process Mitochondrion To Lysosome Vesicle-mediated Transport Negative Regulation Of Protein Oligomerization Regulation Of Locomotion Involved In Locomotory Behavior Tubular Endosome Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Dopamine Metabolic Process Positive Regulation Of Dopamine Receptor Signaling Pathway Voluntary Musculoskeletal Movement Negative Regulation Of RIG-I Signaling Pathway D1 Dopamine Receptor Binding VCP-NPL4-UFD1 AAA ATPase Complex Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane K48-linked Polyubiquitin Modification-dependent Protein Binding Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Regulation Of Lysosomal Protein Catabolic Process Regulation Of Dopamine Receptor Signaling Pathway Neurotransmitter Receptor Transport To Plasma Membrane Mitochondrial Fragmentation Involved In Apoptotic Process Dopaminergic Synapse Regulation Of Dendritic Spine Maintenance Musculoskeletal Movement Endosome To Plasma Membrane Protein Transport Protein Localization To Endosome Neurotransmitter Receptor Transport Retrograde Protein Transport, ER To Cytosol Poly(A) Binding Regulation Of RIG-I Signaling Pathway Transcytosis Regulation Of Dopamine Metabolic Process Positive Regulation Of Mitochondrial Fission Retromer Complex Poly(U) RNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression K63-linked Polyubiquitin Modification-dependent Protein Binding Intracellular Protein Transport
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